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@ARTICLE{Brennich:604000,
      author       = {Brennich, Martha E. and Vainio, Ulla and Wedig, Tatjana and
                      Bauch, Susanne and Herrmann, Harald and Koester, Sarah},
      title        = {{M}utation-induced alterations of intra-filament subunit
                      organization in vimentin filaments revealed by {SAXS}},
      journal      = {Soft matter},
      volume       = {15},
      number       = {9},
      issn         = {1744-683X},
      address      = {London},
      publisher    = {Royal Soc. of Chemistry},
      reportid     = {PUBDB-2024-00965},
      pages        = {1999 - 2008},
      year         = {2019},
      abstract     = {Vimentin intermediate filaments constitute a distinct
                      filament system in mesenchymal cells that is instrumental
                      for cellular mechanics and migration. In vitro, the rod-like
                      monomers assemble in a multi-step, salt-dependent manner
                      into micrometer long biopolymers. To disclose the underlying
                      mechanisms further, we employed small angle X-ray scattering
                      on two recombinant vimentin variants, whose assembly departs
                      at strategic points from the normal assembly route: (i)
                      vimentin with a tyrosine to leucine change at position 117;
                      (ii) vimentin missing the non-α-helical carboxyl-terminal
                      domain. Y117L vimentin assembles into unit-length filaments
                      (ULFs) only, whereas ΔT vimentin assembles into filaments
                      containing a higher number of tetramers per cross section
                      than normal vimentin filaments. We show that the shape and
                      inner structure of these mutant filaments is significantly
                      altered. ULFs assembled from Y117L vimentin contain more,
                      less tightly bundled vimentin tetramers, and ΔT vimentin
                      filaments preserve the number density despite the higher
                      number of tetramers per filament cross-section.},
      cin          = {DOOR ; HAS-User},
      ddc          = {530},
      cid          = {I:(DE-H253)HAS-User-20120731},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-H253)D-B1-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30719518},
      UT           = {WOS:000459932800007},
      doi          = {10.1039/C8SM02281J},
      url          = {https://bib-pubdb1.desy.de/record/604000},
}