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@ARTICLE{Henkel:603124,
      author       = {Henkel, A. and Maracke, J. and Munke, A. and Galchenkova,
                      M. and Rahmani Mashhour, A. and Reinke, P. and Domaracky,
                      Martin and Fleckenstein, Holger and Hakanpää, J. and
                      Meyer, Jan and Tolstikova, A. and Carnis, J. and Middendorf,
                      P. and Gelisio, L. and Yefanov, O. and Chapman, H. N. and
                      Oberthür, D.},
      title        = {{CFEL} {T}ape{D}rive 2.0: a conveyor belt-based
                      sample-delivery system for multi-dimensional serial
                      crystallography},
      journal      = {Acta crystallographica / Section A},
      volume       = {78},
      number       = {a2},
      issn         = {0108-7673},
      address      = {Oxford [u.a.]},
      publisher    = {Blackwell},
      reportid     = {PUBDB-2024-00769},
      pages        = {e560},
      year         = {2022},
      abstract     = {Serial crystallography (SX) at both X-ray free-electron
                      lasers (XFELs) and synchrotrons offers the possibility to
                      collect data at non-cryogenic temperature almost radiation
                      damage free and enables time-resolved crystallography of
                      irreversible reactions. The necessary steady delivery of new
                      micron-sized crystals of biological macromolecules sets it
                      apart from traditional single crystal macromolecular
                      crystallography (MX). For this, many new means of sample
                      delivery have been developed [1]. Described here is a novel
                      conveyor belt-based sample delivery system, the
                      completelyre-designed and reengineered second generation of
                      the CFEL TapeDrive. It is optimized for fast installation at
                      beamlines, ease of use, low sample consumption and precise
                      adjustment of several sample delivery parameters, like
                      ligand concentration, pH and sample temperature. Through
                      combination of these parameters and the additional
                      possibility for time-resolved experiments (delay times of 50
                      ms – 180 s), CFEL TapeDrive 2.0 enables multidimensional
                      serial crystallography experiments. It can now be used as
                      standard instrumentation at beamline P11 at PETRA III (DESY,
                      Germany) and is suitable for serial Laue crystallography
                      with polychromatic X-rays. Additionally, it can be used at
                      XFELs in air (e.g. at SwissFEL and LCLS), offering the
                      possibility to combine the advantages of jet-based injection
                      with those of fixed targetbased systems. In the future,
                      parts of the system will be automated to achieve rapid
                      ligand screening with micron-sized crystals in various
                      sample environments. By introducing the CFEL TapeDrive 2.0,
                      a platform for user-friendly multi-dimensional serial
                      crystallography, we provide a novel approach for structural
                      biology to further reveal details about how macromolecules
                      keep our biological world turning.},
      cin          = {FS-PETRA-D / $FS_FS-SC$ / CFEL-I / FS-CFEL-1-BMX},
      ddc          = {530},
      cid          = {I:(DE-H253)FS-PETRA-D-20210408 /
                      $I:(DE-H253)FS_FS-SC-20201126$ / I:(DE-H253)CFEL-I-20161114
                      / I:(DE-H253)FS-CFEL-1-BMX-20210408},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P11-20150101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:001048207700468},
      doi          = {10.1107/S2053273322092038},
      url          = {https://bib-pubdb1.desy.de/record/603124},
}