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@ARTICLE{Karbelkar:602693,
      author       = {Karbelkar, Amruta A. and Font, Maria and Smith, T. Jarrod
                      and Sondermann, Holger and O’Toole, George A.},
      title        = {{R}econstitution of a {B}iofilm {A}dhesin {S}ystem from a
                      {S}ulfate-{R}educing {B}acterium in {P}seudomonas
                      fluorescens},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      issn         = {0027-8424},
      reportid     = {PUBDB-2024-00739},
      year         = {2023},
      abstract     = {Biofilms of the sulfate reducing bacterium (SRB)
                      Desulfovibrio vulgaris Hildenborough (DvH) can facilitate
                      metal corrosion in various industrial and environmental
                      settings leading to substantial economic losses; however,
                      the mechanisms of biofilm formation by DvH are not yet
                      well-understood. Evidence suggests that a large adhesin,
                      DvhA, may be contributing to biofilm formation in DvH. The
                      dvhA gene and its neighbors encode proteins that resemble
                      the Lap system, which regulates biofilm formation by
                      Pseudomonas fluorescens, including a LapG-like protease DvhG
                      and effector protein DvhD, which has key differences from
                      the previously described LapD. By expressing the Lap-like
                      adhesion components of DvH in P. fluorescens, our data
                      support the model that the N-terminal fragment of the large
                      adhesin DvhA serves as an adhesin “retention module” and
                      is the target of the DvhG/DvhD regulatory module, thereby
                      controlling cell-surface location of the adhesin. By
                      heterologously expressing the DvhG/DvhD-like proteins in a
                      P. fluorescens background lacking native regulation
                      (ΔlapGΔlapD) we also show that cell surface regulation of
                      the adhesin is dependent upon the intracellular levels of
                      c-di-GMP. This study provides insight into the key players
                      responsible for biofilm formation by DvH, thereby expanding
                      our understanding of Lap-like systems.},
      cin          = {CSSB-DESY-HS},
      ddc          = {500},
      cid          = {I:(DE-H253)CSSB-DESY-HS-20210521},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633)},
      pid          = {G:(DE-HGF)POF4-633},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)25},
      pubmed       = {pmid:38045380},
      doi          = {10.1101/2023.11.22.568322},
      url          = {https://bib-pubdb1.desy.de/record/602693},
}