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@ARTICLE{Stinn:602313,
      author       = {Stinn, Anne and Furkert, Jens and Kaufmann, Stefan H. E.
                      and Moura-Alves, Pedro and Kolbe, Michael},
      title        = {{N}ovel {M}ethod for {Q}uantifying {A}h{R}-{L}igand
                      {B}inding {A}ffinities {U}sing {M}icroscale
                      {T}hermophoresis},
      journal      = {Biosensors},
      volume       = {11},
      number       = {3},
      issn         = {2079-6374},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {PUBDB-2024-00588},
      pages        = {60},
      year         = {2021},
      abstract     = {The aryl hydrocarbon receptor (AhR) is a highly conserved
                      cellular sensor of a variety of environmental pollutants and
                      dietary-, cell- and microbiota-derived metabolites with
                      important roles in fundamental biological processes.
                      Deregulation of the AhR pathway is implicated in several
                      diseases, including autoimmune diseases and cancer,
                      rendering AhR a promising target for drug development and
                      host-directed therapy. The pharmacological intervention of
                      AhR processes requires detailed information about the ligand
                      binding properties to allow specific targeting of a
                      particular signaling process without affecting the
                      remaining. Here, we present a novel microscale
                      thermophoresis-based approach to monitoring the binding of
                      purified recombinant human AhR to its natural ligands in a
                      cell-free system. This approach facilitates a precise
                      identification and characterization of unknown AhR ligands
                      and represents a screening strategy for the discovery of
                      potential selective AhR modulators.},
      cin          = {CSSB-HZI-MK},
      ddc          = {570},
      cid          = {I:(DE-H253)CSSB-HZI-MK-20210520},
      pnm          = {899 - ohne Topic (POF4-899) / iNEXT - Infrastructure for
                      NMR, EM and X-rays for translational research (653706)},
      pid          = {G:(DE-HGF)POF4-899 / G:(EU-Grant)653706},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33668313},
      UT           = {WOS:000633434900001},
      doi          = {10.3390/bios11030060},
      url          = {https://bib-pubdb1.desy.de/record/602313},
}