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000602313 1001_ $$0P:(DE-HGF)0$$aStinn, Anne$$b0
000602313 245__ $$aNovel Method for Quantifying AhR-Ligand Binding Affinities Using Microscale Thermophoresis
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000602313 520__ $$aThe aryl hydrocarbon receptor (AhR) is a highly conserved cellular sensor of a variety of environmental pollutants and dietary-, cell- and microbiota-derived metabolites with important roles in fundamental biological processes. Deregulation of the AhR pathway is implicated in several diseases, including autoimmune diseases and cancer, rendering AhR a promising target for drug development and host-directed therapy. The pharmacological intervention of AhR processes requires detailed information about the ligand binding properties to allow specific targeting of a particular signaling process without affecting the remaining. Here, we present a novel microscale thermophoresis-based approach to monitoring the binding of purified recombinant human AhR to its natural ligands in a cell-free system. This approach facilitates a precise identification and characterization of unknown AhR ligands and represents a screening strategy for the discovery of potential selective AhR modulators. 
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000602313 7001_ $$0P:(DE-HGF)0$$aFurkert, Jens$$b1
000602313 7001_ $$0P:(DE-HGF)0$$aKaufmann, Stefan H. E.$$b2
000602313 7001_ $$0P:(DE-HGF)0$$aMoura-Alves, Pedro$$b3$$eCorresponding author
000602313 7001_ $$0P:(DE-H253)PIP1021134$$aKolbe, Michael$$b4$$eCorresponding author
000602313 773__ $$0PERI:(DE-600)2662125-3$$a10.3390/bios11030060$$gVol. 11, no. 3, p. 60 -$$n3$$p60 $$tBiosensors$$v11$$x2079-6374$$y2021
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