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@ARTICLE{Sitarska:602292,
      author       = {Sitarska, Ewa and Almeida, Silvia Dias and Beckwith,
                      Marianne Sandvold and Stopp, Julian and Czuchnowski, Jakub
                      and Siggel, Marc and Roessner, Rita and Tschanz, Aline and
                      Ejsing, Christer and Schwab, Yannick and Kosinski, Jan and
                      Sixt, Michael and Kreshuk, Anna and Erzberger, Anna and
                      Diz-Muñoz, Alba},
      title        = {{S}ensing their plasma membrane curvature allows migrating
                      cells to circumvent obstacles},
      journal      = {Nature Communications},
      volume       = {14},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {PUBDB-2024-00567},
      pages        = {5644},
      year         = {2023},
      abstract     = {To navigate through diverse tissues, migrating cells must
                      balance persistent self-propelled motion with adaptive
                      behaviors to circumvent obstacles. We identify a
                      curvature-sensing mechanism underlying obstacle evasion in
                      immune-like cells. Specifically, we propose that actin
                      polymerization at the advancing edge of migrating cells is
                      inhibited by the curvature-sensitive BAR domain protein
                      Snx33 in regions with inward plasma membrane curvature. The
                      genetic perturbation of this machinery reduces the cells’
                      capacity to evade obstructions combined with faster and more
                      persistent cell migration in obstacle-free environments. Our
                      results show how cells can read out their surface topography
                      and utilize actin and plasma membrane biophysics to
                      interpret their environment, allowing them to adaptively
                      decide if they should move ahead or turn away. On the basis
                      of our findings, we propose that the natural diversity of
                      BAR domain proteins may allow cells to tune their curvature
                      sensing machinery to match the shape characteristics in
                      their environment.},
      cin          = {CSSB-EMBL-JK},
      ddc          = {500},
      cid          = {I:(DE-H253)CSSB-EMBL-JK-20210701},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37704612},
      UT           = {WOS:001087583700008},
      doi          = {10.1038/s41467-023-41173-1},
      url          = {https://bib-pubdb1.desy.de/record/602292},
}