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000602292 1001_ $$0P:(DE-HGF)0$$aSitarska, Ewa$$b0
000602292 245__ $$aSensing their plasma membrane curvature allows migrating cells to circumvent obstacles
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000602292 520__ $$aTo navigate through diverse tissues, migrating cells must balance persistent self-propelled motion with adaptive behaviors to circumvent obstacles. We identify a curvature-sensing mechanism underlying obstacle evasion in immune-like cells. Specifically, we propose that actin polymerization at the advancing edge of migrating cells is inhibited by the curvature-sensitive BAR domain protein Snx33 in regions with inward plasma membrane curvature. The genetic perturbation of this machinery reduces the cells’ capacity to evade obstructions combined with faster and more persistent cell migration in obstacle-free environments. Our results show how cells can read out their surface topography and utilize actin and plasma membrane biophysics to interpret their environment, allowing them to adaptively decide if they should move ahead or turn away. On the basis of our findings, we propose that the natural diversity of BAR domain proteins may allow cells to tune their curvature sensing machinery to match the shape characteristics in their environment. 
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000602292 7001_ $$0P:(DE-HGF)0$$aAlmeida, Silvia Dias$$b1
000602292 7001_ $$0P:(DE-HGF)0$$aBeckwith, Marianne Sandvold$$b2
000602292 7001_ $$0P:(DE-HGF)0$$aStopp, Julian$$b3
000602292 7001_ $$0P:(DE-HGF)0$$aCzuchnowski, Jakub$$b4
000602292 7001_ $$0P:(DE-H253)PIP1097407$$aSiggel, Marc$$b5
000602292 7001_ $$0P:(DE-H253)PIP1100759$$aRoessner, Rita$$b6
000602292 7001_ $$0P:(DE-HGF)0$$aTschanz, Aline$$b7
000602292 7001_ $$0P:(DE-HGF)0$$aEjsing, Christer$$b8
000602292 7001_ $$0P:(DE-HGF)0$$aSchwab, Yannick$$b9
000602292 7001_ $$0P:(DE-H253)PIP1081584$$aKosinski, Jan$$b10
000602292 7001_ $$0P:(DE-HGF)0$$aSixt, Michael$$b11
000602292 7001_ $$0P:(DE-HGF)0$$aKreshuk, Anna$$b12
000602292 7001_ $$0P:(DE-HGF)0$$aErzberger, Anna$$b13
000602292 7001_ $$0P:(DE-HGF)0$$aDiz-Muñoz, Alba$$b14$$eCorresponding author
000602292 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-023-41173-1$$gVol. 14, no. 1, p. 5644$$n1$$p5644$$tNature Communications$$v14$$x2041-1723$$y2023
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