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@ARTICLE{Zhang:601932,
      author       = {Zhang, Chi and Parichenko, Alexandra and Choi, Wonyeong and
                      Shin, Seonghwan and Panes-Ruiz, Luis Antonio and Belyaev,
                      Dmitry and Custódio, Tânia Filipa and Löw, Christian and
                      Lee, Jeong-Soo and Ibarlucea, Bergoi and Cuniberti,
                      Gianaurelio},
      title        = {{S}ybodies as {N}ovel {B}ioreceptors toward
                      {F}ield-{E}ffect {T}ransistor-{B}ased {D}etection of
                      {SARS}-{C}o{V}-2 {A}ntigens},
      journal      = {ACS applied materials $\&$ interfaces},
      volume       = {15},
      number       = {34},
      issn         = {1944-8244},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {PUBDB-2024-00422},
      pages        = {40191 - 40200},
      year         = {2023},
      abstract     = {The SARS-CoV-2 pandemic has increased the demand for
                      low-cost, portable, and rapid biosensors, driving huge
                      research efforts toward new nanomaterial-based approaches
                      with high sensitivity. Many of them employ antibodies as
                      bioreceptors, which have a costly development process that
                      requires animal facilities. Recently, sybodies emerged as a
                      new alternative class of synthetic binders and receptors
                      with high antigen binding efficiency, improved chemical
                      stability, and lower production costs via animal-free
                      methods. Their smaller size is an important asset to
                      consider in combination with ultrasensitive field-effect
                      transistors (FETs) as transducers, which respond more
                      intensely when biorecognition occurs near their surface.
                      This work demonstrates the immobilization of sybodies
                      against the spike protein of the virus on silicon surfaces,
                      which are often integral parts of the semiconducting channel
                      of FETs. Immobilized sybodies maintain the capability to
                      capture antigens, even at low concentrations in the
                      femtomolar range, as observed by fluorescence microscopy.
                      Finally, the first proof of concept of sybody-modified FET
                      sensing is provided using a nanoscopic silicon net as the
                      sensitive area where the sybodies are immobilized. The
                      future development of further sybodies against other
                      biomarkers and their generalization in biosensors could be
                      critical to decrease the cost of biodetection platforms in
                      future pandemics.},
      cin          = {CSSB-EMBL-CL},
      ddc          = {600},
      cid          = {I:(DE-H253)CSSB-EMBL-CL-20210806},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37603713},
      UT           = {WOS:001052038900001},
      doi          = {10.1021/acsami.3c06073},
      url          = {https://bib-pubdb1.desy.de/record/601932},
}