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| 001 | 601922 | ||
| 005 | 20250715172810.0 | ||
| 024 | 7 | _ | |a 10.1016/j.cell.2023.10.002 |2 doi |
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| 100 | 1 | _ | |a Simonis, Alexander |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa |
| 260 | _ | _ | |a New York, NY |c 2023 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a Waiting for fulltext |
| 520 | _ | _ | |a Drug-resistant Pseudomonas aeruginosa (PA) poses an emerging threat to human health with urgent need for alternative therapeutic approaches. Here, we deciphered the B cell and antibody response to the virulence-associated type III secretion system (T3SS) in a cohort of patients chronically infected with PA. Single-cell analytics revealed a diverse B cell receptor repertoire directed against the T3SS needle-tip protein PcrV, enabling the production of monoclonal antibodies (mAbs) abrogating T3SS-mediated cytotoxicity. Mechanistic studies involving cryoelectron microscopy identified a surface-exposed C-terminal PcrV epitope as the target of highly neutralizing mAbs with broad activity against drug-resistant PA isolates. These anti-PcrV mAbs were as effective as treatment with conventional antibiotics in vivo. Our study reveals that chronically infected patients represent a source of neutralizing antibodies, which can be exploited as therapeutics against PA. |
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| 700 | 1 | _ | |a Kreer, Christoph |b 1 |
| 700 | 1 | _ | |a Albus, Alexandra |b 2 |
| 700 | 1 | _ | |a Rox, Katharina |b 3 |
| 700 | 1 | _ | |a Yuan, Biao |0 P:(DE-H253)PIP1091457 |b 4 |
| 700 | 1 | _ | |a Holzmann, Dmitriy |b 5 |
| 700 | 1 | _ | |a Wilms, Joana A. |b 6 |
| 700 | 1 | _ | |a Zuber, Sylvia |b 7 |
| 700 | 1 | _ | |a Kottege, Lisa |b 8 |
| 700 | 1 | _ | |a Winter, Sandra |b 9 |
| 700 | 1 | _ | |a Meyer, Meike |b 10 |
| 700 | 1 | _ | |a Schmitt, Kristin |b 11 |
| 700 | 1 | _ | |a Gruell, Henning |b 12 |
| 700 | 1 | _ | |a Theobald, Sebastian J. |b 13 |
| 700 | 1 | _ | |a Hellmann, Anna-Maria |b 14 |
| 700 | 1 | _ | |a Meyer, Christina |b 15 |
| 700 | 1 | _ | |a Ercanoglu, Meryem Seda |b 16 |
| 700 | 1 | _ | |a Cramer, Nina |b 17 |
| 700 | 1 | _ | |a Munder, Antje |b 18 |
| 700 | 1 | _ | |a Hallek, Michael |b 19 |
| 700 | 1 | _ | |a Fätkenheuer, Gerd |b 20 |
| 700 | 1 | _ | |a Koch, Manuel |b 21 |
| 700 | 1 | _ | |a Seifert, Harald |b 22 |
| 700 | 1 | _ | |a Rietschel, Ernst |b 23 |
| 700 | 1 | _ | |a Marlovits, Thomas |0 P:(DE-H253)PIP1021412 |b 24 |
| 700 | 1 | _ | |a van Koningsbruggen-Rietschel, Silke |b 25 |
| 700 | 1 | _ | |a Klein, Florian |b 26 |
| 700 | 1 | _ | |a Rybniker, Jan |0 P:(DE-HGF)0 |b 27 |e Corresponding author |
| 773 | _ | _ | |a 10.1016/j.cell.2023.10.002 |g Vol. 186, no. 23, p. 5098 - 5113.e19 |0 PERI:(DE-600)2001951-8 |n 23 |p 5098 - 5113 |t Cell |v 186 |y 2023 |x 0092-8674 |
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