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@ARTICLE{Simonis:601922,
      author       = {Simonis, Alexander and Kreer, Christoph and Albus,
                      Alexandra and Rox, Katharina and Yuan, Biao and Holzmann,
                      Dmitriy and Wilms, Joana A. and Zuber, Sylvia and Kottege,
                      Lisa and Winter, Sandra and Meyer, Meike and Schmitt,
                      Kristin and Gruell, Henning and Theobald, Sebastian J. and
                      Hellmann, Anna-Maria and Meyer, Christina and Ercanoglu,
                      Meryem Seda and Cramer, Nina and Munder, Antje and Hallek,
                      Michael and Fätkenheuer, Gerd and Koch, Manuel and Seifert,
                      Harald and Rietschel, Ernst and Marlovits, Thomas and van
                      Koningsbruggen-Rietschel, Silke and Klein, Florian and
                      Rybniker, Jan},
      title        = {{D}iscovery of highly neutralizing human antibodies
                      targeting {P}seudomonas aeruginosa},
      journal      = {Cell},
      volume       = {186},
      number       = {23},
      issn         = {0092-8674},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2024-00412},
      pages        = {5098 - 5113},
      year         = {2023},
      note         = {Waiting for fulltext},
      abstract     = {Drug-resistant Pseudomonas aeruginosa (PA) poses an
                      emerging threat to human health with urgent need for
                      alternative therapeutic approaches. Here, we deciphered the
                      B cell and antibody response to the virulence-associated
                      type III secretion system (T3SS) in a cohort of patients
                      chronically infected with PA. Single-cell analytics revealed
                      a diverse B cell receptor repertoire directed against the
                      T3SS needle-tip protein PcrV, enabling the production of
                      monoclonal antibodies (mAbs) abrogating T3SS-mediated
                      cytotoxicity. Mechanistic studies involving cryoelectron
                      microscopy identified a surface-exposed C-terminal PcrV
                      epitope as the target of highly neutralizing mAbs with broad
                      activity against drug-resistant PA isolates. These anti-PcrV
                      mAbs were as effective as treatment with conventional
                      antibiotics in vivo. Our study reveals that chronically
                      infected patients represent a source of neutralizing
                      antibodies, which can be exploited as therapeutics against
                      PA.},
      cin          = {CSSB-UKE-TM / FS-CS},
      ddc          = {610},
      cid          = {I:(DE-H253)CSSB-UKE-TM-20210520 /
                      I:(DE-H253)FS-CS-20210408},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633)},
      pid          = {G:(DE-HGF)POF4-633},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37918395},
      UT           = {WOS:001116377000001},
      doi          = {10.1016/j.cell.2023.10.002},
      url          = {https://bib-pubdb1.desy.de/record/601922},
}