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@ARTICLE{Otto:601681,
      author       = {Otto, Ferdinand and Dallari, Francesco and Westermeier,
                      Fabian and Wieland, D. C. Florian and Parak, Wolfgang J. and
                      Lehmkühler, Felix and Schulz, Florian},
      title        = {{T}he dynamics of {PEG}‐coated nanoparticles in
                      concentrated protein solutions up to the molecular crowding
                      range},
      journal      = {Aggregate},
      volume       = {5},
      number       = {3},
      issn         = {2692-4560},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {PUBDB-2024-00373},
      pages        = {e483},
      year         = {2024},
      abstract     = {Polymer-coated nanoparticles are widely studied in the
                      context of nanomedicine and it is therefore of utmost
                      importance to understand not only how their structure but
                      also how their colloidal dynamics are affected by
                      physiologically relevant conditions. A characteristic
                      feature of the cytosol of cells is the very high
                      concentration of proteins among other matrix components,
                      often termed macromolecular crowding. Here, the structure
                      and colloidal dynamics of poly(ethylene glycol) (PEG)-coated
                      gold nanoparticles in the presence of bovine serum albumin
                      (BSA) concentrations ranging from 0 to 265 mg/mL are studied
                      with X-ray photon correlation spectroscopy. For
                      protein–nanoparticle mixtures with high BSA
                      concentrations, comparable to intracellular levels, a
                      significant deviation of the apparent viscosity from
                      expectations for pure BSA solutions is found. The findings
                      strongly indicate that the nanoscopic viscous properties of
                      the dense protein solutions are significantly affected by
                      the nanoparticles. At these high concentrations, the
                      colloidal stability of the samples depends on the molecular
                      weight of the coating PEG–ligand, whereas at lower
                      concentrations no differences are observed.},
      cin          = {FS-SMP / FS-CXS / FS-PETRA-S / UNI/CUI},
      ddc          = {600},
      cid          = {I:(DE-H253)FS-SMP-20171124 / I:(DE-H253)FS-CXS-20130727 /
                      I:(DE-H253)FS-PETRA-S-20210408 /
                      $I:(DE-H253)UNI_CUI-20121230$},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / GRK 2536 - GRK 2536:
                      Hybridstrukturen auf der Nanometerskala: Chemische Konzepte
                      zur Herstellung heterogener Nanostrukturen mit anisotropen
                      Materialeigenschaften (NANOHYBRID) (408076438) / DFG project
                      G:(GEPRIS)390715994 - EXC 2056: CUI: Advanced Imaging of
                      Matter (390715994)},
      pid          = {G:(DE-HGF)POF4-633 / G:(GEPRIS)408076438 /
                      G:(GEPRIS)390715994},
      experiment   = {EXP:(DE-MLZ)External-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:001136383900001},
      doi          = {10.1002/agt2.483},
      url          = {https://bib-pubdb1.desy.de/record/601681},
}