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@ARTICLE{Ferreira:601560,
      author       = {Ferreira, Josie L. and Pražák, Vojtěch and Vasishtan,
                      Daven and Siggel, Marc and Hentzschel, Franziska and Binder,
                      Annika M. and Pietsch, Emma and Kosinski, Jan and
                      Frischknecht, Friedrich and Gilberger, Tim W. and
                      Gruenewald, Kay},
      title        = {{V}ariable microtubule architecture in the malaria
                      parasite},
      journal      = {Nature Communications},
      volume       = {14},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {PUBDB-2024-00269},
      pages        = {1216},
      year         = {2023},
      note         = {German Center for Infection Research, DZIF (FH), DFG-FR
                      2140/10-1 (AMB), DFG research networks SFB 1129, SPP 2332
                      and grant FR 2140/10-1 (FF), CSSB KIF-002 (TWG and KG), DFG
                      research networks SPP 2225 (TWG)},
      abstract     = {Microtubules are a ubiquitous eukaryotic cytoskeletal
                      element typically consisting of 13 protofilaments arranged
                      in a hollow cylinder. This arrangement is considered the
                      canonical form and is adopted by most organisms, with rare
                      exceptions. Here, we use in situ electron cryo-tomography
                      and subvolume averaging to analyse the changing microtubule
                      cytoskeleton of Plasmodium falciparum, the causative agent
                      of malaria, throughout its life cycle. Unexpectedly,
                      different parasite forms have distinct microtubule
                      structures coordinated by unique organising centres. In
                      merozoites, the most widely studied form, we observe
                      canonical microtubules. In migrating mosquito forms, the 13
                      protofilament structure is further reinforced by interrupted
                      luminal helices. Surprisingly, gametocytes contain a wide
                      distribution of microtubule structures ranging from 13 to 18
                      protofilaments, doublets and triplets. Such a diversity of
                      microtubule structures has not been observed in any other
                      organism to date and is likely evidence of a distinct role
                      in each life cycle form. This data provides a unique view
                      into an unusual microtubule cytoskeleton of a relevant human
                      pathogen.},
      cin          = {CSSB-BNITM-TG / CSSB-LIV-KG / CSSB-EMBL-JK / CSSB-CF-CRYO},
      ddc          = {500},
      cid          = {I:(DE-H253)CSSB-BNITM-TG-20210520 /
                      I:(DE-H253)CSSB-LIV-KG-20220525 /
                      I:(DE-H253)CSSB-EMBL-JK-20210701 /
                      I:(DE-H253)CSSB-CF-CRYO-20210520},
      pnm          = {899 - ohne Topic (POF4-899) / EIPOD4 - EMBL
                      Interdisciplinary Postdoc Programme 4 (847543)},
      pid          = {G:(DE-HGF)POF4-899 / G:(EU-Grant)847543},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36869034},
      UT           = {WOS:001066713800005},
      doi          = {10.1038/s41467-023-36627-5},
      url          = {https://bib-pubdb1.desy.de/record/601560},
}