Home > Publications database > Designed inhibitors to reduce amyloid virulence and cytotoxicity and combat neurodegenerative and infectious diseases > print

001     596160
005     20250715173700.0
024 7 _ |a 10.1016/j.cbpa.2023.102318
|2 doi
024 7 _ |a 1367-5931
|2 ISSN
024 7 _ |a 1879-0402
|2 ISSN
024 7 _ |a 10.3204/PUBDB-2023-06091
|2 datacite_doi
024 7 _ |a altmetric:148656546
|2 altmetric
024 7 _ |a pmid:37196450
|2 pmid
024 7 _ |a WOS:001001125500001
|2 WOS
024 7 _ |2 openalex
|a openalex:W4376627464
037 _ _ |a PUBDB-2023-06091
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Indig, Rinat Yona
|b 0
245 _ _ |a Designed inhibitors to reduce amyloid virulence and cytotoxicity and combat neurodegenerative and infectious diseases
260 _ _ |a London
|c 2023
|b Current Biology Ltd.
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1697180725_1552382
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a The review highlights the role of amyloids in various diseases and the challenges associated with targeting human amyloids in therapeutic development. However, due to the better understanding of microbial amyloids' role as virulence factors, there is a growing interest in repurposing and designing anti-amyloid compounds for antivirulence therapy. The identification of amyloid inhibitors has not only significant clinical implications but also provides valuable insights into the structure and function of amyloids. The review showcases small molecules and peptides that specifically target amyloids in both humans and microbes, reducing cytotoxicity and biofilm formation, respectively. The review emphasizes the importance of further research on amyloid structures, mechanisms, and interactions across all life forms to yield new drug targets and improve the design of selective treatments. Overall, the review highlights the potential for amyloid inhibitors in therapeutic development for both human diseases and microbial infections.
536 _ _ |a 633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633)
|0 G:(DE-HGF)POF4-633
|c POF4-633
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, Journals: bib-pubdb1.desy.de
693 _ _ |0 EXP:(DE-MLZ)NOSPEC-20140101
|5 EXP:(DE-MLZ)NOSPEC-20140101
|e No specific instrument
|x 0
700 1 _ |a Landau, Meytal
|0 P:(DE-H253)PIP1026961
|b 1
|e Corresponding author
773 _ _ |a 10.1016/j.cbpa.2023.102318
|g Vol. 75, p. 102318 -
|0 PERI:(DE-600)2019216-2
|p 102318
|t Current opinion in chemical biology
|v 75
|y 2023
|x 1367-5931
856 4 _ |y Restricted
|u https://bib-pubdb1.desy.de/record/596160/files/1-s2.0-S136759312300056X-main.pdf
856 4 _ |y Published on 2023-08-01. Available in OpenAccess from 2024-08-01.
|u https://bib-pubdb1.desy.de/record/596160/files/Indig_InhibitorReview2023_revised_20230410_NoHighlight.pdf
856 4 _ |y Restricted
|x pdfa
|u https://bib-pubdb1.desy.de/record/596160/files/1-s2.0-S136759312300056X-main.pdf?subformat=pdfa
856 4 _ |y Published on 2023-08-01. Available in OpenAccess from 2024-08-01.
|x pdfa
|u https://bib-pubdb1.desy.de/record/596160/files/Indig_InhibitorReview2023_revised_20230410_NoHighlight.pdf?subformat=pdfa
909 C O |o oai:bib-pubdb1.desy.de:596160
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Centre for Structural Systems Biology
|0 I:(DE-H253)_CSSB-20140311
|k CSSB
|b 1
|6 P:(DE-H253)PIP1026961
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 1
|6 P:(DE-H253)PIP1026961
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 1
|6 P:(DE-H253)PIP1026961
913 1 _ |a DE-HGF
|b Forschungsbereich Materie
|l Von Materie zu Materialien und Leben
|1 G:(DE-HGF)POF4-630
|0 G:(DE-HGF)POF4-633
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-600
|4 G:(DE-HGF)POF
|v Life Sciences – Building Blocks of Life: Structure and Function
|x 0
914 1 _ |y 2023
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2023-10-22
915 _ _ |a Embargoed OpenAccess
|0 StatID:(DE-HGF)0530
|2 StatID
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b CURR OPIN CHEM BIOL : 2022
|d 2023-10-22
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2023-08-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2023-10-22
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2023-10-22
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b CURR OPIN CHEM BIOL : 2022
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1120
|2 StatID
|b BIOSIS Reviews Reports And Meetings
|d 2023-10-22
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2023-08-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2023-10-22
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
|d 2023-10-22
|w ger
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2023-10-22
920 1 _ |0 I:(DE-H253)CSSB-F-20230420
|k CSSB-F
|l FPF Functional Protein Fibrils
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-H253)CSSB-F-20230420
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21