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@ARTICLE{Indig:596160,
      author       = {Indig, Rinat Yona and Landau, Meytal},
      title        = {{D}esigned inhibitors to reduce amyloid virulence and
                      cytotoxicity and combat neurodegenerative and infectious
                      diseases},
      journal      = {Current opinion in chemical biology},
      volume       = {75},
      issn         = {1367-5931},
      address      = {London},
      publisher    = {Current Biology Ltd.},
      reportid     = {PUBDB-2023-06091},
      pages        = {102318},
      year         = {2023},
      abstract     = {The review highlights the role of amyloids in various
                      diseases and the challenges associated with targeting human
                      amyloids in therapeutic development. However, due to the
                      better understanding of microbial amyloids' role as
                      virulence factors, there is a growing interest in
                      repurposing and designing anti-amyloid compounds for
                      antivirulence therapy. The identification of amyloid
                      inhibitors has not only significant clinical implications
                      but also provides valuable insights into the structure and
                      function of amyloids. The review showcases small molecules
                      and peptides that specifically target amyloids in both
                      humans and microbes, reducing cytotoxicity and biofilm
                      formation, respectively. The review emphasizes the
                      importance of further research on amyloid structures,
                      mechanisms, and interactions across all life forms to yield
                      new drug targets and improve the design of selective
                      treatments. Overall, the review highlights the potential for
                      amyloid inhibitors in therapeutic development for both human
                      diseases and microbial infections.},
      cin          = {CSSB-F},
      ddc          = {570},
      cid          = {I:(DE-H253)CSSB-F-20230420},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633)},
      pid          = {G:(DE-HGF)POF4-633},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37196450},
      UT           = {WOS:001001125500001},
      doi          = {10.1016/j.cbpa.2023.102318},
      url          = {https://bib-pubdb1.desy.de/record/596160},
}