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@ARTICLE{Rolvien:593875,
      author       = {Rolvien, Tim and Nagel, Florian and Milovanovic, Petar and
                      Wuertz, Sven and Marshall, Robert Percy and Jeschke, Anke
                      and Schmidt, Felix N. and Hahn, Michael and Witten, P.
                      Eckhard and Amling, Michael and Busse, Björn},
      title        = {{H}ow the {E}uropean eel ( {A}nguilla anguilla ) loses its
                      skeletal framework across lifetime},
      journal      = {Proceedings of the Royal Society of London / B},
      volume       = {283},
      number       = {1841},
      issn         = {0080-4649},
      address      = {London},
      publisher    = {The Royal Society},
      reportid     = {PUBDB-2023-05541},
      pages        = {20161550 -},
      year         = {2016},
      note         = {PIF‐2014‐28},
      abstract     = {European eels (Anguilla anguilla) undertake an impressive 5
                      000 km long migration from European fresh waters through the
                      North Atlantic Ocean to the Sargasso Sea. Along with sexual
                      maturation, the eel skeleton undergoes a remarkable
                      morphological transformation during migration, where a
                      hitherto completely obscure bone loss phenomenon occurs. To
                      unravel mechanisms of the maturation-related decay of the
                      skeleton, we performed a multiscale assessment of eels'
                      bones at different life-cycle stages. Accordingly, the
                      skeleton reflects extensive bone loss that is mediated via
                      multinucleated bone-resorbing osteoclasts, while other
                      resorption mechanisms such as osteocytic osteolysis or
                      matrix demineralization were not observed. Preserving
                      mechanical stability and releasing minerals for energy
                      metabolism are two mutually exclusive functions of the
                      skeleton that are orchestrated in eels through the presence
                      of two spatially segregated hard tissues: cellular bone and
                      acellular notochord. The cellular bone serves as a source of
                      mineral release following osteoclastic resorption, whereas
                      the mineralized notochord sheath, which is inaccessible for
                      resorption processes due to an unmineralized cover layer,
                      ensures sufficient mechanical stability as a part of the
                      notochord sheath. Clearly, an eel's skeleton is structurally
                      optimized to meet the metabolic challenge of fasting and
                      simultaneous sexual development during an exhausting journey
                      to spawning areas, while the function of the vertebral
                      column is maintained to achieve this goal.},
      ddc          = {570},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1098/rspb.2016.1550},
      url          = {https://bib-pubdb1.desy.de/record/593875},
}