TY  - JOUR
AU  - Ginn, Helen
TI  - Torsion angles to map and visualize the conformational space of a protein
JO  - Protein science
VL  - 32
IS  - 4
SN  - 0961-8368
CY  - Bethesda, Md.
PB  - Protein Society
M1  - PUBDB-2023-00952
SP  - e4608
PY  - 2023
N1  - License CC-BY
AB  - Present understanding of protein structure dynamics trails behind that of static structures. A torsion angle based approach, called representation of protein entities (RoPE), derives an interpretable conformational space which correlates with data collection temperature, resolution and reaction coordinate. For more complex systems, atomic coordinates fail to separate functional conformational states, which are still preserved by torsion angle-derived space. This indicates that torsion angles are often a more sensitive and biologically relevant descriptor for protein conformational dynamics than atomic coordinates.
LB  - PUB:(DE-HGF)16
C6  - 36840926
UR  - <Go to ISI:>//WOS:000949309400001
DO  - DOI:10.1002/pro.4608
UR  - https://bib-pubdb1.desy.de/record/578456
ER  -