000521655 001__ 521655
000521655 005__ 20240927184151.0
000521655 0247_ $$aG:(GEPRIS)193205741$$d193205741
000521655 035__ $$aG:(GEPRIS)193205741
000521655 040__ $$aGEPRIS$$chttp://gepris.its.kfa-juelich.de
000521655 150__ $$aLichttransport durch die Retina: Optik der Wirbeltiernetzhaut$$y2011 - 2017
000521655 371__ $$aProfessor Dr. Andreas Reichenbach
000521655 450__ $$aDFG project G:(GEPRIS)193205741$$wd$$y2011 - 2017
000521655 5101_ $$0I:(DE-588b)2007744-0$$aDeutsche Forschungsgemeinschaft$$bDFG
000521655 680__ $$aIt is an old enigma how the vertebrate retina can function properly despite being inverted: light must pass all (light scattering) retinal layers before it can be detected by the photoreceptor cells. Recently we have shown that Müller radial glial cells act as light guiding fibers, bypassing the inner retinal layers. However, this light guidance must end at the outer nuclear layer where the Müller cell processes split into thin cytoplasmic tongues. Our collaborating partner has forwarded the hypothesis that the radial rows of photoreceptor cell nuclei serve as ‘chains of lenses’ bridging the distance between the Müller cell stem processes and the photoreceptor inner segments. To test this hypothesis and to elucidate the complex light path through the entire retina, we will perform (i) a quantitative analysis of the numerical relation between the subsequent light-guiding elements, (ii) a structural analysis of the ‘transition zone(s)’ between them, and (iii) a direct visualization of light transfer through the retina. For the latter purpose, laser light will be applied by a thin fiber to the inner surface of the retina. The light path of the laser beam will be monitored, as well as the fluorescence induced by it within the structures of the retina, labeled by fluorescent vital dyes. In collaboration with the partner in Cambridge, mathematical modeling of light transport through the retina will be performed.
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000521655 909CO $$ooai:juser.fz-juelich.de:947386
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