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@INPROCEEDINGS{Taberman:517549,
      author       = {Taberman, Helena and Borges Perdomo, Clemente and
                      Chatziefthymiou, Spyridon and Crosas Ubeda, Eva and
                      Gruzinov, Andrey and Kistner, Bernhard and Pompidor,
                      Guillaume and Song, jialing and Hakanpaeae, Johanna},
      title        = {{T}he {H}igh-{T}roughput {M}acromolecular {C}rystallography
                      {B}eamline {P}11 at {PETRA} {III}},
      reportid     = {PUBDB-2023-00532},
      year         = {2022},
      abstract     = {P11 at PETRA III (DESY, Hamburg) is a high-throughput
                      instrument for macromolecular crystallography (1). P11 has
                      tuneable photon energy between 5.5 - 28 keV having the
                      Eiger2 X 16M as the stationary detector and the possibility
                      of using a CdTe-detector for higher energies. Beam size from
                      200 x 200 μm to 4 x 9 μm can be used with a maximum photon
                      flux of 1.3 x $10^13$ ph/s at 12 keV energy. The automatic
                      sample changer at P11 is based on the unipuck format with a
                      total capacity of 23 pucks (368 samples) having a
                      mount-unmount cycle of approximately 36 s, which brings the
                      beamtime spent per sample down to ca. 2min. Furthermore, in
                      close proximity of the beamline, P11 has a user laboratory
                      with e.g. a crystal shifter for semi-automated crystal
                      harvesting.During the past two years mode of operation at
                      P11 has changed from fully on-site to almost exclusively
                      remote. Remote connection using FastX-access via a dedicated
                      remote machine was established in 2020, which has enabled
                      near normal user operation throughout the pandemic. Users
                      are supported by a virtual meeting and the scientific
                      accounts can be used during and after the beamtime for
                      manual data processing on Maxwell, the central computational
                      cluster, where the autoprocessing is also migrated to the
                      dedicated P11 nodes.P11 is a very diverse environment and
                      allows the adjustment to various non-standard experiments
                      e.g. via the long term proposal (LTP) scheme. For example,
                      serial synchrotron crystallography at P11 is enabled with
                      sample delivery through various types of solid supports or
                      the tape-drive setup, which enables time-resolved
                      experiments by the mix-and diffuse method (2), and has been
                      developed through the LTP scheme along with the real-time
                      autoprocessing of serial data with CrystFEL (3). This year
                      MXCuBE will be employed as the default control software with
                      the integration to ISPyB for tracking shipments,
                      communicating the sample details to MXCuBE, as well as
                      acting as a data archive. The establishment of parallel
                      autoprocessing pipelines in addition to the currently used,
                      XDSAPP-based (4) pipeline, and the implementation of
                      strategy calculation including dose estimation are also
                      planned. Furthermore, these software developments are
                      synchronising P11 with the EMBL PETRA III beamlines for the
                      future foundation of a uniform structural biology village at
                      PETRA IV.[1] Burkhardt A., et al., Status of the
                      crystallography beamlines at PETRA III. Eur. Phys. J. Plus
                      131, 56 (2016)[2] Beyerlein K. R., et al., Mix-and-diffuse
                      serial synchrotron crystallography. IUCrJ 4, 769-777
                      (2017)[3] White T. A., et al., Recent developments in
                      CrystFEL. J. Appl. Cryst. 49, 680-689 (2016)[4] Sparta KM,
                      et al., XDSAPP2.0. J. Appl. Cryst. 49, 1085-1092 (2016)},
      month         = {Jul},
      date          = {2022-07-23},
      organization  = {33rd European Crystallographic
                       Meeting, Versailles (France), 23 Jul
                       2022 - 27 Jul 2022},
      cin          = {FS-PETRA-D / ITT},
      cid          = {I:(DE-H253)FS-PETRA-D-20210408 / I:(DE-H253)ITT-20160816},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P11-20150101},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://bib-pubdb1.desy.de/record/517549},
}