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@ARTICLE{Gruber:491728,
      author       = {Gruber, Karl and Csitkovits, Vanessa and Łyskowski,
                      Andrzej and Kratky, Christoph and Kräutler, Bernhard},
      title        = {{S}tructure‐{B}ased {D}emystification of {R}adical
                      {C}atalysis by a {C}oenzyme {B}$_{12}$ {D}ependent
                      {E}nzyme—{C}rystallographic {S}tudy of {G}lutamate
                      {M}utase with {C}ofactor {H}omologues},
      journal      = {Angewandte Chemie},
      volume       = {134},
      number       = {35},
      issn         = {0932-2132},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {PUBDB-2023-00367},
      pages        = {e202208295},
      year         = {2022},
      abstract     = {Catalysis by radical enzymes dependent on coenzyme B$_{12}$
                      (AdoCbl) relies on the reactive primary
                      5′-deoxy-5′adenosyl radical, which originates from
                      reversible Co−C bond homolysis of AdoCbl. This bond
                      homolysis is accelerated roughly 10$^{12}$-fold upon binding
                      the enzyme substrate. The structural basis for this
                      activation is still strikingly enigmatic. As revealed here,
                      a displaced firm adenosine binding cavity in
                      substrate-loaded glutamate mutase (GM) causes a structural
                      misfit for intact AdoCbl that is relieved by the homolytic
                      Co−C bond cleavage. Strategically interacting adjacent
                      adenosine- and substrate-binding protein cavities provide a
                      tight caged radical reaction space, controlling the entire
                      radical path. The GM active site is perfectly structured for
                      promoting radical catalysis, including “negative
                      catalysis”, a paradigm for AdoCbl-dependent mutases.},
      cin          = {DOOR ; HAS-User},
      ddc          = {660},
      cid          = {I:(DE-H253)HAS-User-20120731},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      experiment   = {EXP:(DE-H253)D-BW7-20150101},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1002/ange.202208295},
      url          = {https://bib-pubdb1.desy.de/record/491728},
}