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000491479 1001_ $$0P:(DE-H253)PIP1020283$$aLane, Thomas$$b0$$eCorresponding author$$udesy
000491479 245__ $$aProtein structure prediction has reached the single-structure frontier
000491479 260__ $$aLondon [u.a.]$$bNature Publishing Group$$c2023
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000491479 520__ $$aDramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are currently limited by the fact that they predict only a single structure, instead of a structural distribution, and that this realization is crucial for the next generation of structure prediction algorithms.
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000491479 773__ $$0PERI:(DE-600)2163081-1$$a10.1038/s41592-022-01760-4$$gVol. 20, no. 2, p. 170 - 173$$n2$$p170 - 173$$tNature methods$$v20$$x1548-7091$$y2023
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