%0 Journal Article
%A Lane, Thomas
%T Protein structure prediction has reached the single-structure frontier
%J Nature methods
%V 20
%N 2
%@ 1548-7091
%C London [u.a.]
%I Nature Publishing Group
%M PUBDB-2023-00183
%P 170 - 173
%D 2023
%X Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are currently limited by the fact that they predict only a single structure, instead of a structural distribution, and that this realization is crucial for the next generation of structure prediction algorithms.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 36639584
%U <Go to ISI:>//WOS:000913553400001
%R 10.1038/s41592-022-01760-4
%U https://bib-pubdb1.desy.de/record/491479