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@ARTICLE{Ko:485846,
      author       = {Ko, Kuang-Ting and Lennartz, Frank and Mekhaiel, David and
                      Guloglu, Bora and Marini, Arianna and Deuker, Danielle J.
                      and Long, Carole A. and Jore, Matthijs M. and Miura,
                      Kazutoyo and Biswas, Sumi and Higgins, Matthew K.},
      title        = {{S}tructure of the malaria vaccine candidate {P}fs48/45 and
                      its recognition by transmission blocking antibodies},
      journal      = {Nature Communications},
      volume       = {13},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {PUBDB-2022-06895},
      pages        = {5603},
      year         = {2022},
      abstract     = {An effective malaria vaccine remains a global health
                      priority and vaccine immunogens which prevent transmission
                      of the parasite will have important roles in multi-component
                      vaccines. One of the most promising candidates for inclusion
                      in a transmission-blocking malaria vaccine is the gamete
                      surface protein Pfs48/45, which is essential for development
                      of the parasite in the mosquito midgut. Indeed, antibodies
                      which bind Pfs48/45 can prevent transmission if ingested
                      with the parasite as part of the mosquito bloodmeal. Here we
                      present the structure of full-length Pfs48/45, showing its
                      three domains to form a dynamic, planar, triangular
                      arrangement. We reveal where transmission-blocking and
                      non-blocking antibodies bind on Pfs48/45. Finally, we
                      demonstrate that antibodies which bind across this molecule
                      can be transmission-blocking. These studies will guide the
                      development of future Pfs48/45-based vaccine immunogens.},
      cin          = {EMBL-User},
      ddc          = {500},
      cid          = {I:(DE-H253)EMBL-User-20120814},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P12-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36153317},
      UT           = {WOS:000858076500002},
      doi          = {10.1038/s41467-022-33379-6},
      url          = {https://bib-pubdb1.desy.de/record/485846},
}