TY  - JOUR
AU  - Ko, Kuang-Ting
AU  - Lennartz, Frank
AU  - Mekhaiel, David
AU  - Guloglu, Bora
AU  - Marini, Arianna
AU  - Deuker, Danielle J.
AU  - Long, Carole A.
AU  - Jore, Matthijs M.
AU  - Miura, Kazutoyo
AU  - Biswas, Sumi
AU  - Higgins, Matthew K.
TI  - Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies
JO  - Nature Communications
VL  - 13
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - PUBDB-2022-06895
SP  - 5603
PY  - 2022
AB  - An effective malaria vaccine remains a global health priority and vaccine immunogens which prevent transmission of the parasite will have important roles in multi-component vaccines. One of the most promising candidates for inclusion in a transmission-blocking malaria vaccine is the gamete surface protein Pfs48/45, which is essential for development of the parasite in the mosquito midgut. Indeed, antibodies which bind Pfs48/45 can prevent transmission if ingested with the parasite as part of the mosquito bloodmeal. Here we present the structure of full-length Pfs48/45, showing its three domains to form a dynamic, planar, triangular arrangement. We reveal where transmission-blocking and non-blocking antibodies bind on Pfs48/45. Finally, we demonstrate that antibodies which bind across this molecule can be transmission-blocking. These studies will guide the development of future Pfs48/45-based vaccine immunogens.
LB  - PUB:(DE-HGF)16
C6  - pmid:36153317
UR  - <Go to ISI:>//WOS:000858076500002
DO  - DOI:10.1038/s41467-022-33379-6
UR  - https://bib-pubdb1.desy.de/record/485846
ER  -