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@ARTICLE{Vzquez:484512,
author = {Vázquez, Cecilia Alejandra and Widerspick, Lina and
Thünauer, Roland and Schneider, Carola and Reimer, Rudolph
and Neira, Pedro and Olal, Catherine and Heung, Michelle and
Niemetz, Linda and Lawrence, Philip and Kucinskaite-Kodze,
Indre and Redecke, Lars and Escudero-Pérez, Beatriz},
title = {{N}ipah {V}irus {I}nfection {G}enerates {O}rdered
{S}tructures in {C}ellulo},
journal = {Viruses},
volume = {14},
number = {7},
issn = {1999-4915},
address = {Basel},
publisher = {MDPI},
reportid = {PUBDB-2022-06325},
pages = {1523},
year = {2022},
abstract = {Nipah virus (NiV) is a zoonotic paramyxovirus with a
fatality rate of up to $92\%$ in humans. While several
pathogenic mechanisms used by NiV to counteract host immune
defense responses have been described, all of the processes
that take place in cells during infection are not fully
characterized. Here, we describe the formation of ordered
intracellular structures during NiV infection. We observed
that these structures are formed specifically during NiV
infection, but not with other viruses from the same
Mononegavirales order (namely Ebola virus) or from other
orders such as Bunyavirales (Junín virus). We also
determined the kinetics of the appearance of these
structures and their cellular localization at the cellular
periphery. Finally, we confirmed the presence of these
NiV-specific ordered structures using structured
illumination microscopy (SIM), as well as their localization
by transmission electron microscopy (TEM), scanning electron
microscopy (SEM), and correlative light and electron
microscopy (CLEM). Herein, we describe a cytopathogenic
mechanism that provides a new insight into NiV biology.
These newly described ordered structures could provide a
target for novel antiviral approaches.},
cin = {DOOR ; HAS-User / U Lübeck / CSSB-CF-ALFM},
ddc = {050},
cid = {I:(DE-H253)HAS-User-20120731 /
$I:(DE-H253)U_L__beck-20211012$ /
I:(DE-H253)CSSB-CF-ALFM-20210629},
pnm = {633 - Life Sciences – Building Blocks of Life: Structure
and Function (POF4-633) / 6G3 - PETRA III (DESY) (POF4-6G3)},
pid = {G:(DE-HGF)POF4-633 / G:(DE-HGF)POF4-6G3},
experiment = {EXP:(DE-H253)P-P14-20150101},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35891503},
UT = {WOS:000831704200001},
doi = {10.3390/v14071523},
url = {https://bib-pubdb1.desy.de/record/484512},
}