Home > Publications database > Inhibition of SARS-CoV-2 main protease by allosteric drug-binding > print

001     482633
005     20240619144721.0
024 7 _ |a 10.1101/2020.11.12.378422
|2 doi
024 7 _ |a altmetric:94185717
|2 altmetric
037 _ _ |a PUBDB-2022-04874
041 _ _ |a English
082 _ _ |a 320
100 1 _ |a Günther, Sebastian
|0 P:(DE-H253)PIP1082033
|b 0
|e Corresponding author
245 _ _ |a Inhibition of SARS-CoV-2 main protease by allosteric drug-binding
260 _ _ |c 2020
336 7 _ |a Preprint
|b preprint
|m preprint
|0 PUB:(DE-HGF)25
|s 1718801126_3742813
|2 PUB:(DE-HGF)
336 7 _ |a WORKING_PAPER
|2 ORCID
336 7 _ |a Electronic Article
|0 28
|2 EndNote
336 7 _ |a preprint
|2 DRIVER
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a Output Types/Working Paper
|2 DataCite
520 _ _ |a The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous health problems and economical challenges for mankind. To date, no effective drug is available to directly treat the disease and prevent virus spreading. In a search for a drug against COVID-19, we have performed a massive X-ray crystallographic screen of two repurposing drug libraries against the SARS-CoV-2 main protease (Mpro), which is essential for the virus replication and, thus, a potent drug target. In contrast to commonly applied X-ray fragment screening experiments with molecules of low complexity, our screen tested already approved drugs and drugs in clinical trials. From the three-dimensional protein structures, we identified 37 compounds binding to M$^{pro}$. In subsequent cell-based viral reduction assays, one peptidomimetic and five non-peptidic compounds showed antiviral activity at non-toxic concentrations. We identified two allosteric binding sites representing attractive targets for drug development against SARS-CoV-2.
536 _ _ |a 633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633)
|0 G:(DE-HGF)POF4-633
|c POF4-633
|f POF IV
|x 0
536 _ _ |a 6G3 - PETRA III (DESY) (POF4-6G3)
|0 G:(DE-HGF)POF4-6G3
|c POF4-6G3
|f POF IV
|x 1
536 _ _ |a HIDSS-0002 - DASHH: Data Science in Hamburg - Helmholtz Graduate School for the Structure of Matter (2019_IVF-HIDSS-0002)
|0 G:(DE-HGF)2019_IVF-HIDSS-0002
|c 2019_IVF-HIDSS-0002
|x 2
536 _ _ |a DFG project 194651731 - EXC 1074: Hamburger Zentrum für ultraschnelle Beobachtung (CUI): Struktur, Dynamik und Kontrolle von Materie auf atomarer Skala (194651731)
|0 G:(GEPRIS)194651731
|c 194651731
|x 3
536 _ _ |a DFG project 390715994 - EXC 2056: CUI: Advanced Imaging of Matter (390715994)
|0 G:(GEPRIS)390715994
|c 390715994
|x 4
588 _ _ |a Dataset connected to CrossRef
693 _ _ |a PETRA III
|f PETRA Beamline P11
|1 EXP:(DE-H253)PETRAIII-20150101
|0 EXP:(DE-H253)P-P11-20150101
|6 EXP:(DE-H253)P-P11-20150101
|x 0
693 _ _ |a PETRA III
|f PETRA Beamline P13
|1 EXP:(DE-H253)PETRAIII-20150101
|0 EXP:(DE-H253)P-P13-20150101
|6 EXP:(DE-H253)P-P13-20150101
|x 1
693 _ _ |a PETRA III
|f PETRA Beamline P14
|1 EXP:(DE-H253)PETRAIII-20150101
|0 EXP:(DE-H253)P-P14-20150101
|6 EXP:(DE-H253)P-P14-20150101
|x 2
700 1 _ |a Reinke, Patrick Y. A.
|0 P:(DE-H253)PIP1082068
|b 1
700 1 _ |a Fernández-García, Yaiza
|0 P:(DE-H253)PIP1087056
|b 2
700 1 _ |a Lieske, Julia
|0 P:(DE-H253)PIP1031014
|b 3
700 1 _ |a Lane, Thomas J.
|0 P:(DE-H253)PIP1020283
|b 4
700 1 _ |a Ginn, Helen M.
|0 P:(DE-H253)PIP1032871
|b 5
700 1 _ |a Koua, Faisal H. M.
|0 P:(DE-HGF)0
|b 6
700 1 _ |a Ehrt, Christiane
|b 7
700 1 _ |a Ewert, Wiebke
|0 P:(DE-H253)PIP1082863
|b 8
700 1 _ |a Oberthuer, Dominik
|0 P:(DE-H253)PIP1012087
|b 9
700 1 _ |a Yefanov, Oleksandr
|0 P:(DE-H253)PIP1006155
|b 10
700 1 _ |a Meier, Susanne
|0 P:(DE-H253)PIP1000018
|b 11
700 1 _ |a Lorenzen, Kristina
|0 P:(DE-H253)PIP1022131
|b 12
700 1 _ |a Krichel, Boris
|0 P:(DE-H253)PIP1018823
|b 13
700 1 _ |a Kopicki, Janine-Denise
|0 P:(DE-H253)PIP1029871
|b 14
700 1 _ |a Gelisio, Luca
|0 P:(DE-H253)PIP1028523
|b 15
700 1 _ |a Brehm, Wolfgang
|0 P:(DE-H253)PIP1033390
|b 16
700 1 _ |a Dunkel, Ilona
|b 17
700 1 _ |a Seychell, Brandon
|0 P:(DE-H253)PIP1033037
|b 18
700 1 _ |a Gieseler, Henry
|0 P:(DE-H253)PIP1032011
|b 19
700 1 _ |a Norton-Baker, Brenna
|0 P:(DE-H253)PIP1090270
|b 20
700 1 _ |a Escudero-Pérez, Beatriz
|b 21
700 1 _ |a Domaracky, Martin
|0 P:(DE-H253)PIP1020481
|b 22
700 1 _ |a Saouane, Sofiane
|0 P:(DE-H253)PIP1015657
|b 23
700 1 _ |a Tolstikova, Alexandra
|0 P:(DE-H253)PIP1020246
|b 24
700 1 _ |a White, Thomas A.
|0 P:(DE-H253)PIP1010779
|b 25
700 1 _ |a Hänle, Anna
|0 P:(DE-H253)PIP1093252
|b 26
700 1 _ |a Groessler, Michael
|0 P:(DE-H253)PIP1091853
|b 27
700 1 _ |a Fleckenstein, Holger
|0 P:(DE-H253)PIP1011659
|b 28
700 1 _ |a Trost, Fabian
|0 P:(DE-H253)PIP1082226
|b 29
700 1 _ |a Galchenkova, Marina
|0 P:(DE-H253)PIP1081165
|b 30
700 1 _ |a Gevorkov, Yaroslav
|0 P:(DE-H253)PIP1027420
|b 31
700 1 _ |a Li, Chufeng
|0 P:(DE-H253)PIP1089491
|b 32
700 1 _ |a Awel, Salah
|0 P:(DE-H253)PIP1020096
|b 33
700 1 _ |a Peck, Ariana
|b 34
700 1 _ |a Barthelmess, Miriam
|0 P:(DE-H253)PIP1005287
|b 35
700 1 _ |a Schluenzen, Frank
|0 P:(DE-H253)PIP1005464
|b 36
700 1 _ |a Lourdu Xavier, Paulraj
|b 37
700 1 _ |a Werner, Nadine
|0 P:(DE-H253)PIP1025876
|b 38
700 1 _ |a Andaleeb, Hina
|0 P:(DE-H253)PIP1086930
|b 39
700 1 _ |a Ullah, Najeeb
|0 P:(DE-H253)PIP1082946
|b 40
700 1 _ |a Falke, Sven
|0 P:(DE-H253)PIP1089186
|b 41
700 1 _ |a Srinivasan, Vasundara
|0 P:(DE-H253)PIP1080622
|b 42
700 1 _ |a França, Bruno Alves
|0 P:(DE-H253)PIP1090308
|b 43
700 1 _ |a Schwinzer, Martin
|0 P:(DE-H253)PIP1091585
|b 44
700 1 _ |a Brognaro, Hévila
|0 P:(DE-H253)PIP1083097
|b 45
700 1 _ |a Rogers, Cromarte
|b 46
700 1 _ |a Melo, Diogo
|b 47
700 1 _ |a Zaitseva-Doyle, Joanna J.
|b 48
700 1 _ |a Knoska, Juraj
|0 P:(DE-H253)PIP1020244
|b 49
700 1 _ |a Peña-Murillo, Gisel E.
|b 50
700 1 _ |a Mashhour, Aida Rahmani
|b 51
700 1 _ |a Hennicke, Vincent
|0 P:(DE-H253)PIP1029485
|b 52
700 1 _ |a Fischer, Pontus
|0 P:(DE-H253)PIP1011948
|b 53
700 1 _ |a Hakanpää, Johanna
|0 P:(DE-H253)PIP1013442
|b 54
700 1 _ |a Meyer, Jan
|0 P:(DE-H253)PIP1016998
|b 55
700 1 _ |a Gribbon, Philip
|b 56
700 1 _ |a Ellinger, Bernhard
|b 57
700 1 _ |a Kuzikov, Maria
|b 58
700 1 _ |a Wolf, Markus
|b 59
700 1 _ |a Beccari, Andrea R.
|b 60
700 1 _ |a Bourenkov, Gleb
|0 P:(DE-H253)PIP1007425
|b 61
700 1 _ |a von Stetten, David
|0 P:(DE-H253)PIP1083129
|b 62
700 1 _ |a Pompidor, Guillaume
|0 P:(DE-H253)PIP1018389
|b 63
700 1 _ |a Bento, Isabel
|b 64
700 1 _ |a Panneerselvam, Saravanan
|0 P:(DE-H253)PIP1000022
|b 65
700 1 _ |a Karpics, Ivars
|b 66
700 1 _ |a Schneider, Thomas R.
|0 P:(DE-H253)PIP1005932
|b 67
700 1 _ |a Garcia-Alai, Maria Marta
|b 68
700 1 _ |a Niebling, Stephan
|b 69
700 1 _ |a Guenther, Christian
|0 P:(DE-H253)PIP1088971
|b 70
700 1 _ |a Schmidt, Christina
|0 P:(DE-H253)PIP1026698
|b 71
700 1 _ |a Schubert, Robin
|0 P:(DE-H253)PIP1018164
|b 72
700 1 _ |a Han, Huijong
|0 P:(DE-H253)PIP1015711
|b 73
700 1 _ |a Boger, Juliane
|b 74
700 1 _ |a Monteiro, Diana C. F.
|0 P:(DE-H253)PIP1028233
|b 75
700 1 _ |a Zhang, Linlin
|b 76
700 1 _ |a Sun, Xinyuanyuan
|b 77
700 1 _ |a Pletzer-Zelgert, Jonathan
|b 78
700 1 _ |a Wollenhaupt, Jan
|0 P:(DE-H253)PIP1026924
|b 79
700 1 _ |a Feiler, Christian G.
|0 P:(DE-H253)PIP1027437
|b 80
700 1 _ |a Weiss, Manfred S.
|b 81
700 1 _ |a Schulz, Eike-Christian
|0 P:(DE-H253)PIP1019225
|b 82
700 1 _ |a Mehrabi, Pedram
|0 P:(DE-H253)PIP1029103
|b 83
700 1 _ |a Karničar, Katarina
|b 84
700 1 _ |a Usenik, Aleksandra
|b 85
700 1 _ |a Loboda, Jure
|b 86
700 1 _ |a Tidow, Henning
|0 P:(DE-H253)PIP1011252
|b 87
700 1 _ |a Chari, Ashwin
|b 88
700 1 _ |a Hilgenfeld, Rolf
|b 89
700 1 _ |a Uetrecht, Charlotte
|0 P:(DE-H253)PIP1014042
|b 90
700 1 _ |a Cox, Russell
|b 91
700 1 _ |a Zaliani, Andrea
|b 92
700 1 _ |a Beck, Tobias
|0 P:(DE-H253)PIP1090581
|b 93
700 1 _ |a Rarey, Matthias
|0 P:(DE-H253)PIP1087358
|b 94
700 1 _ |a Günther, Stephan
|b 95
700 1 _ |a Turk, Dusan
|0 P:(DE-H253)PIP1081105
|b 96
700 1 _ |a Hinrichs, Winfried
|0 P:(DE-H253)PIP1032408
|b 97
700 1 _ |a Chapman, Henry N.
|0 P:(DE-H253)PIP1006324
|b 98
700 1 _ |a Pearson, Arwen R.
|0 P:(DE-H253)PIP1022042
|b 99
700 1 _ |a Betzel, Christian
|0 P:(DE-H253)PIP1002913
|b 100
700 1 _ |a Meents, Alke
|0 P:(DE-H253)PIP1006208
|b 101
773 _ _ |a 10.1101/2020.11.12.378422
856 4 _ |u https://bib-pubdb1.desy.de/record/482633/files/2020.11.12.378422.full.pdf
|y Restricted
856 4 _ |u https://bib-pubdb1.desy.de/record/482633/files/2020.11.12.378422.full.pdf?subformat=pdfa
|x pdfa
|y Restricted
909 C O |p VDB
|o oai:bib-pubdb1.desy.de:482633
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 0
|6 P:(DE-H253)PIP1082033
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 0
|6 P:(DE-H253)PIP1082033
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 0
|6 P:(DE-H253)PIP1082033
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 1
|6 P:(DE-H253)PIP1082068
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 1
|6 P:(DE-H253)PIP1082068
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 2
|6 P:(DE-H253)PIP1087056
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 2
|6 P:(DE-H253)PIP1087056
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 3
|6 P:(DE-H253)PIP1031014
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 3
|6 P:(DE-H253)PIP1031014
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 3
|6 P:(DE-H253)PIP1031014
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 4
|6 P:(DE-H253)PIP1020283
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 4
|6 P:(DE-H253)PIP1020283
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 5
|6 P:(DE-H253)PIP1032871
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 5
|6 P:(DE-H253)PIP1032871
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 8
|6 P:(DE-H253)PIP1082863
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 8
|6 P:(DE-H253)PIP1082863
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 8
|6 P:(DE-H253)PIP1082863
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 9
|6 P:(DE-H253)PIP1012087
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 9
|6 P:(DE-H253)PIP1012087
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 9
|6 P:(DE-H253)PIP1012087
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 10
|6 P:(DE-H253)PIP1006155
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 10
|6 P:(DE-H253)PIP1006155
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 10
|6 P:(DE-H253)PIP1006155
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 11
|6 P:(DE-H253)PIP1000018
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 11
|6 P:(DE-H253)PIP1000018
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 12
|6 P:(DE-H253)PIP1022131
910 1 _ |a Centre for Structural Systems Biology
|0 I:(DE-H253)_CSSB-20140311
|k CSSB
|b 13
|6 P:(DE-H253)PIP1018823
910 1 _ |a Centre for Structural Systems Biology
|0 I:(DE-H253)_CSSB-20140311
|k CSSB
|b 14
|6 P:(DE-H253)PIP1029871
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 15
|6 P:(DE-H253)PIP1028523
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 15
|6 P:(DE-H253)PIP1028523
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 15
|6 P:(DE-H253)PIP1028523
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 16
|6 P:(DE-H253)PIP1033390
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 16
|6 P:(DE-H253)PIP1033390
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 18
|6 P:(DE-H253)PIP1033037
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 18
|6 P:(DE-H253)PIP1033037
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 18
|6 P:(DE-H253)PIP1033037
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 19
|6 P:(DE-H253)PIP1032011
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 19
|6 P:(DE-H253)PIP1032011
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 19
|6 P:(DE-H253)PIP1032011
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 20
|6 P:(DE-H253)PIP1090270
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 20
|6 P:(DE-H253)PIP1090270
910 1 _ |a Max-Planck-Gesellschaft zur Förderung der Wissenschaften
|0 I:(DE-588b)2019024-4
|k MPG
|b 20
|6 P:(DE-H253)PIP1090270
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 22
|6 P:(DE-H253)PIP1020481
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 22
|6 P:(DE-H253)PIP1020481
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 23
|6 P:(DE-H253)PIP1015657
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 23
|6 P:(DE-H253)PIP1015657
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 24
|6 P:(DE-H253)PIP1020246
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 24
|6 P:(DE-H253)PIP1020246
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 25
|6 P:(DE-H253)PIP1010779
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 25
|6 P:(DE-H253)PIP1010779
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 25
|6 P:(DE-H253)PIP1010779
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 26
|6 P:(DE-H253)PIP1093252
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 26
|6 P:(DE-H253)PIP1093252
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 27
|6 P:(DE-H253)PIP1091853
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 28
|6 P:(DE-H253)PIP1011659
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 28
|6 P:(DE-H253)PIP1011659
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 28
|6 P:(DE-H253)PIP1011659
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 29
|6 P:(DE-H253)PIP1082226
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 29
|6 P:(DE-H253)PIP1082226
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 30
|6 P:(DE-H253)PIP1081165
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 30
|6 P:(DE-H253)PIP1081165
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 30
|6 P:(DE-H253)PIP1081165
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 31
|6 P:(DE-H253)PIP1027420
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 31
|6 P:(DE-H253)PIP1027420
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 32
|6 P:(DE-H253)PIP1089491
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 32
|6 P:(DE-H253)PIP1089491
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 32
|6 P:(DE-H253)PIP1089491
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 33
|6 P:(DE-H253)PIP1020096
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 33
|6 P:(DE-H253)PIP1020096
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 35
|6 P:(DE-H253)PIP1005287
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 35
|6 P:(DE-H253)PIP1005287
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 35
|6 P:(DE-H253)PIP1005287
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 36
|6 P:(DE-H253)PIP1005464
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 36
|6 P:(DE-H253)PIP1005464
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 38
|6 P:(DE-H253)PIP1025876
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 39
|6 P:(DE-H253)PIP1086930
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 39
|6 P:(DE-H253)PIP1086930
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 40
|6 P:(DE-H253)PIP1082946
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 40
|6 P:(DE-H253)PIP1082946
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 41
|6 P:(DE-H253)PIP1089186
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 41
|6 P:(DE-H253)PIP1089186
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 41
|6 P:(DE-H253)PIP1089186
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 42
|6 P:(DE-H253)PIP1080622
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 42
|6 P:(DE-H253)PIP1080622
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 43
|6 P:(DE-H253)PIP1090308
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 44
|6 P:(DE-H253)PIP1091585
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 44
|6 P:(DE-H253)PIP1091585
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 45
|6 P:(DE-H253)PIP1083097
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 45
|6 P:(DE-H253)PIP1083097
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 45
|6 P:(DE-H253)PIP1083097
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 49
|6 P:(DE-H253)PIP1020244
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 49
|6 P:(DE-H253)PIP1020244
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 52
|6 P:(DE-H253)PIP1029485
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 52
|6 P:(DE-H253)PIP1029485
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 52
|6 P:(DE-H253)PIP1029485
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 53
|6 P:(DE-H253)PIP1011948
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 53
|6 P:(DE-H253)PIP1011948
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 53
|6 P:(DE-H253)PIP1011948
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 54
|6 P:(DE-H253)PIP1013442
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 55
|6 P:(DE-H253)PIP1016998
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 55
|6 P:(DE-H253)PIP1016998
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 55
|6 P:(DE-H253)PIP1016998
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 61
|6 P:(DE-H253)PIP1007425
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 61
|6 P:(DE-H253)PIP1007425
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 62
|6 P:(DE-H253)PIP1083129
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 63
|6 P:(DE-H253)PIP1018389
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 63
|6 P:(DE-H253)PIP1018389
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 65
|6 P:(DE-H253)PIP1000022
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 65
|6 P:(DE-H253)PIP1000022
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 67
|6 P:(DE-H253)PIP1005932
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 70
|6 P:(DE-H253)PIP1088971
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 71
|6 P:(DE-H253)PIP1026698
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 71
|6 P:(DE-H253)PIP1026698
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 72
|6 P:(DE-H253)PIP1018164
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 73
|6 P:(DE-H253)PIP1015711
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 75
|6 P:(DE-H253)PIP1028233
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 75
|6 P:(DE-H253)PIP1028233
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 79
|6 P:(DE-H253)PIP1026924
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 79
|6 P:(DE-H253)PIP1026924
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 80
|6 P:(DE-H253)PIP1027437
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 80
|6 P:(DE-H253)PIP1027437
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 82
|6 P:(DE-H253)PIP1019225
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 83
|6 P:(DE-H253)PIP1029103
910 1 _ |a Max-Planck-Gesellschaft zur Förderung der Wissenschaften
|0 I:(DE-588b)2019024-4
|k MPG
|b 83
|6 P:(DE-H253)PIP1029103
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 83
|6 P:(DE-H253)PIP1029103
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 87
|6 P:(DE-H253)PIP1011252
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 87
|6 P:(DE-H253)PIP1011252
910 1 _ |a Centre for Structural Systems Biology
|0 I:(DE-H253)_CSSB-20140311
|k CSSB
|b 90
|6 P:(DE-H253)PIP1014042
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 90
|6 P:(DE-H253)PIP1014042
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 93
|6 P:(DE-H253)PIP1090581
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 93
|6 P:(DE-H253)PIP1090581
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 93
|6 P:(DE-H253)PIP1090581
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 94
|6 P:(DE-H253)PIP1087358
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 96
|6 P:(DE-H253)PIP1081105
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 97
|6 P:(DE-H253)PIP1032408
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 98
|6 P:(DE-H253)PIP1006324
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 98
|6 P:(DE-H253)PIP1006324
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 98
|6 P:(DE-H253)PIP1006324
910 1 _ |a European Molecular Biology Laboratory
|0 I:(DE-588b)235011-7
|k EMBL
|b 99
|6 P:(DE-H253)PIP1022042
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 99
|6 P:(DE-H253)PIP1022042
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 99
|6 P:(DE-H253)PIP1022042
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 100
|6 P:(DE-H253)PIP1002913
910 1 _ |a Deutsches Elektronen-Synchrotron
|0 I:(DE-588b)2008985-5
|k DESY
|b 101
|6 P:(DE-H253)PIP1006208
910 1 _ |a Centre for Free-Electron Laser Science
|0 I:(DE-H253)_CFEL-20120731
|k CFEL
|b 101
|6 P:(DE-H253)PIP1006208
910 1 _ |a European XFEL
|0 I:(DE-588)1043621512
|k XFEL.EU
|b 101
|6 P:(DE-H253)PIP1006208
913 1 _ |a DE-HGF
|b Forschungsbereich Materie
|l Von Materie zu Materialien und Leben
|1 G:(DE-HGF)POF4-630
|0 G:(DE-HGF)POF4-633
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-600
|4 G:(DE-HGF)POF
|v Life Sciences – Building Blocks of Life: Structure and Function
|x 0
913 1 _ |a DE-HGF
|b Forschungsbereich Materie
|l Großgeräte: Materie
|1 G:(DE-HGF)POF4-6G0
|0 G:(DE-HGF)POF4-6G3
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-600
|4 G:(DE-HGF)POF
|v PETRA III (DESY)
|x 1
915 _ _ |a Published
|0 StatID:(DE-HGF)0580
|2 StatID
920 1 _ |0 I:(DE-H253)CFEL-I-20161114
|k CFEL-I
|l FS-CFEL-1 (Group Leader: Henry Chapman)
|x 0
920 1 _ |0 I:(DE-H253)CFEL-TRSB-20161025
|k CFEL-TRSB
|l Arwen Pearson - CUI
|x 1
920 1 _ |0 I:(DE-H253)FS-PET-D-20190712
|k FS-PET-D
|l Experimentebetreuung PETRA III
|x 2
920 1 _ |0 I:(DE-H253)FS_FS-SC-20201126
|k FS_FS-SC
|l FS_FS-SC
|x 3
920 1 _ |0 I:(DE-H253)IT-20120731
|k IT
|l Informationstechnologie
|x 4
920 1 _ |0 I:(DE-H253)EMBL-20120731
|k EMBL
|l EMBL
|x 5
920 1 _ |0 I:(DE-H253)U_HH-20120814
|k U HH
|l Uni Hamburg
|x 6
920 1 _ |0 I:(DE-H253)FS-CSSB-GS-20140815
|k FS-CSSB-GS
|l Centre for Structural Systems Biology
|x 7
920 1 _ |0 I:(DE-H253)CFEL-ARD-20160914
|k CFEL-ARD
|l MPSD
|x 8
920 1 _ |0 I:(DE-H253)Eur_XFEL-20120731
|k Eur.XFEL
|l European XFEL Projekt Team
|x 9
980 _ _ |a preprint
980 _ _ |a VDB
980 _ _ |a I:(DE-H253)CFEL-I-20161114
980 _ _ |a I:(DE-H253)CFEL-TRSB-20161025
980 _ _ |a I:(DE-H253)FS-PET-D-20190712
980 _ _ |a I:(DE-H253)FS_FS-SC-20201126
980 _ _ |a I:(DE-H253)IT-20120731
980 _ _ |a I:(DE-H253)EMBL-20120731
980 _ _ |a I:(DE-H253)U_HH-20120814
980 _ _ |a I:(DE-H253)FS-CSSB-GS-20140815
980 _ _ |a I:(DE-H253)CFEL-ARD-20160914
980 _ _ |a I:(DE-H253)Eur_XFEL-20120731
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21