guest ::
| Home > Publications database > N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum > print |
| Home > Publications database > N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum > print |
| 001 | 476470 | ||
| 005 | 20250724151417.0 | ||
| 024 | 7 | _ | |a 10.1042/BCJ20210829 |2 doi |
| 024 | 7 | _ | |a 0264-6021 |2 ISSN |
| 024 | 7 | _ | |a 1470-8728 |2 ISSN |
| 024 | 7 | _ | |a 10.3204/PUBDB-2022-01747 |2 datacite_doi |
| 024 | 7 | _ | |a altmetric:120822488 |2 altmetric |
| 024 | 7 | _ | |a pmid:35023554 |2 pmid |
| 024 | 7 | _ | |a WOS:000753051700001 |2 WOS |
| 024 | 7 | _ | |a openalex:W4220750441 |2 openalex |
| 037 | _ | _ | |a PUBDB-2022-01747 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Pazicky, Samuel |0 P:(DE-H253)PIP1080467 |b 0 |
| 245 | _ | _ | |a N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum |
| 260 | _ | _ | |a London [u.a.] |c 2022 |b Portland Pr. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1717066490_148986 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a ISSN 1470-8728 not unique: **2 hits**. |
| 520 | _ | _ | |a As the decline of malaria cases stalled over the last five years, novel targets in Plasmodium falciparum are necessary for the development of new drugs. Glycogen Synthase Kinase (PfGSK3) has been identified as a potential target, since its selective inhibitors were shown to disrupt the parasitès life cycle. In the uncanonical N-terminal region of the parasite enzyme, we identified several autophosphorylation sites and probed their role in activity regulation of PfGSK3. By combining molecular modeling with experimental small-angle X-ray scattering data, we show that increased PfGSK3 activity is promoted by conformational changes in the PfGSK3 N-terminus, triggered by N-terminal phosphorylation. Our work provides novel insights into the structure and regulation of the malarial PfGSK3. |
| 536 | _ | _ | |a 6G3 - PETRA III (DESY) (POF4-6G3) |0 G:(DE-HGF)POF4-6G3 |c POF4-6G3 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, Journals: bib-pubdb1.desy.de |
| 693 | _ | _ | |a PETRA III |f PETRA Beamline P12 |1 EXP:(DE-H253)PETRAIII-20150101 |0 EXP:(DE-H253)P-P12-20150101 |6 EXP:(DE-H253)P-P12-20150101 |x 0 |
| 700 | 1 | _ | |a Alder, Arne |b 1 |
| 700 | 1 | _ | |a Mertens, Haydyn |b 2 |
| 700 | 1 | _ | |a Svergun, Dmitri |b 3 |
| 700 | 1 | _ | |a Gilberger, Tim |b 4 |
| 700 | 1 | _ | |a Loew, Christian |0 P:(DE-H253)PIP1023783 |b 5 |e Corresponding author |
| 773 | _ | _ | |a 10.1042/BCJ20210829 |g Vol. 479, no. 3, p. 337 - 356 |0 PERI:(DE-600)2007050-0 |n 3 |p 337 - 356 |t The @biochemical journal / Reviews |v 479 |y 2022 |x 0264-6021 |
| 856 | 4 | _ | |u https://portlandpress.com/biochemj/article/479/3/337/230649/N-terminal-phosphorylation-regulates-the-activity |
| 856 | 4 | _ | |u https://bib-pubdb1.desy.de/record/476470/files/N%20terminal%20phosphorylation%20regulates%20the%20activity%20of%20glycogen%20synthase%20kinase%203%20from%20Plasmodium%20falciparum.pdf |y OpenAccess |
| 856 | 4 | _ | |u https://bib-pubdb1.desy.de/record/476470/files/N%20terminal%20phosphorylation%20regulates%20the%20activity%20of%20glycogen%20synthase%20kinase%203%20from%20Plasmodium%20falciparum.pdf?subformat=pdfa |x pdfa |y OpenAccess |
| 909 | C | O | |o oai:bib-pubdb1.desy.de:476470 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Centre for Structural Systems Biology |0 I:(DE-H253)_CSSB-20140311 |k CSSB |b 0 |6 P:(DE-H253)PIP1080467 |
| 910 | 1 | _ | |a Centre for Structural Systems Biology |0 I:(DE-H253)_CSSB-20140311 |k CSSB |b 5 |6 P:(DE-H253)PIP1023783 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Materie |l Großgeräte: Materie |1 G:(DE-HGF)POF4-6G0 |0 G:(DE-HGF)POF4-6G3 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-600 |4 G:(DE-HGF)POF |v PETRA III (DESY) |x 0 |
| 914 | 1 | _ | |y 2022 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b BIOCHEM J : 2013 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 920 | 1 | _ | |0 I:(DE-H253)EMBL-User-20120814 |k EMBL-User |l EMBL-User |x 0 |
| 920 | 1 | _ | |0 I:(DE-H253)EMBL-20120731 |k EMBL |l EMBL |x 1 |
| 920 | 1 | _ | |0 I:(DE-H253)CSSB-EMBL-20141216 |k CSSB-EMBL |l CSSB-EMBL |x 2 |
| 920 | 1 | _ | |0 I:(DE-H253)CSSB-EMBL-CL-20210806 |k CSSB-EMBL-CL |l CSSB-EMBL-CL |x 3 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-H253)EMBL-User-20120814 |
| 980 | _ | _ | |a I:(DE-H253)EMBL-20120731 |
| 980 | _ | _ | |a I:(DE-H253)CSSB-EMBL-20141216 |
| 980 | _ | _ | |a I:(DE-H253)CSSB-EMBL-CL-20210806 |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|