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@ARTICLE{Pazicky:476470,
      author       = {Pazicky, Samuel and Alder, Arne and Mertens, Haydyn and
                      Svergun, Dmitri and Gilberger, Tim and Loew, Christian},
      title        = {{N}-terminal phosphorylation regulates the activity of
                      glycogen synthase kinase 3 from {P}lasmodium falciparum},
      journal      = {The biochemical journal / Reviews},
      volume       = {479},
      number       = {3},
      issn         = {0264-6021},
      address      = {London [u.a.]},
      publisher    = {Portland Pr.},
      reportid     = {PUBDB-2022-01747},
      pages        = {337 - 356},
      year         = {2022},
      note         = {ISSN 1470-8728 not unique: **2 hits**.},
      abstract     = {As the decline of malaria cases stalled over the last five
                      years, novel targets in Plasmodium falciparum are necessary
                      for the development of new drugs. Glycogen Synthase Kinase
                      (PfGSK3) has been identified as a potential target, since
                      its selective inhibitors were shown to disrupt the
                      parasitès life cycle. In the uncanonical N-terminal region
                      of the parasite enzyme, we identified several
                      autophosphorylation sites and probed their role in activity
                      regulation of PfGSK3. By combining molecular modeling with
                      experimental small-angle X-ray scattering data, we show that
                      increased PfGSK3 activity is promoted by conformational
                      changes in the PfGSK3 N-terminus, triggered by N-terminal
                      phosphorylation. Our work provides novel insights into the
                      structure and regulation of the malarial PfGSK3.},
      cin          = {EMBL-User / EMBL / CSSB-EMBL / CSSB-EMBL-CL},
      ddc          = {540},
      cid          = {I:(DE-H253)EMBL-User-20120814 / I:(DE-H253)EMBL-20120731 /
                      I:(DE-H253)CSSB-EMBL-20141216 /
                      I:(DE-H253)CSSB-EMBL-CL-20210806},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P12-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35023554},
      UT           = {WOS:000753051700001},
      doi          = {10.1042/BCJ20210829},
      url          = {https://bib-pubdb1.desy.de/record/476470},
}