000474421 001__ 474421
000474421 005__ 20250724151343.0
000474421 0247_ $$2doi$$a10.1042/BST20210526
000474421 0247_ $$2ISSN$$a0300-5127
000474421 0247_ $$2ISSN$$a1470-8752
000474421 0247_ $$2datacite_doi$$a10.3204/PUBDB-2022-00779
000474421 0247_ $$2altmetric$$aaltmetric:119703343
000474421 0247_ $$2pmid$$apmid:34940787
000474421 0247_ $$2WOS$$aWOS:000736185200001
000474421 0247_ $$2openalex$$aopenalex:W4200599813
000474421 037__ $$aPUBDB-2022-00779
000474421 041__ $$aEnglish
000474421 082__ $$a540
000474421 1001_ $$aPeters, Thomas$$b0
000474421 245__ $$aNorovirus–glycan interactions — how strong are they really?
000474421 260__ $$aLondon$$bBiochemical Society$$c2022
000474421 3367_ $$2DRIVER$$aarticle
000474421 3367_ $$2DataCite$$aOutput Types/Journal article
000474421 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1675167549_18267
000474421 3367_ $$2BibTeX$$aARTICLE
000474421 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000474421 3367_ $$00$$2EndNote$$aJournal Article
000474421 520__ $$aInfection with human noroviruses requires attachment to histo blood group antigens (HBGAs) via the major capsid protein VP1 as a primary step. Several crystal structures of VP1 protruding domain dimers, so called P-dimers, complexed with different HBGAs have been solved to atomic resolution. Corresponding binding affinities have been determined for HBGAs and other glycans exploiting different biophysical techniques, with mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy being most widely used. However, reported binding affinities are inconsistent. At the extreme, for the same system MS detects binding whereas NMR spectroscopy does not, suggesting a fundamental source of error. In this short essay, we will explain the reason for the observed differences and compile reliable and reproducible binding affinities. We will then highlight how a combination of MS techniques and NMR experiments affords unique insights into the process of HBGA binding by norovirus capsid proteins.
000474421 536__ $$0G:(DE-HGF)POF4-633$$a633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633)$$cPOF4-633$$fPOF IV$$x0
000474421 588__ $$aDataset connected to CrossRef, Journals: bib-pubdb1.desy.de
000474421 693__ $$0EXP:(DE-MLZ)NOSPEC-20140101$$5EXP:(DE-MLZ)NOSPEC-20140101$$eNo specific instrument$$x0
000474421 7001_ $$aCreutznacher, Robert$$b1
000474421 7001_ $$aMaass, Thorben$$b2
000474421 7001_ $$aMallagaray, Alvaro$$b3
000474421 7001_ $$aOgrissek, Patrick$$b4
000474421 7001_ $$0P:(DE-H253)PIP1031058$$aTaube, Stefan$$b5
000474421 7001_ $$0P:(DE-H253)PIP1097669$$aThiede, Lars$$b6
000474421 7001_ $$0P:(DE-H253)PIP1014042$$aUetrecht, Charlotte$$b7$$eCorresponding author
000474421 773__ $$0PERI:(DE-600)2007367-7$$a10.1042/BST20210526$$gp. BST20210526$$n1$$p347 – 359$$tBiochemical Society transactions$$v50$$x0300-5127$$y2022
000474421 8564_ $$uhttps://bib-pubdb1.desy.de/record/474421/files/bst-2021-0526c.pdf$$yOpenAccess
000474421 8564_ $$uhttps://bib-pubdb1.desy.de/record/474421/files/bst-2021-0526c.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000474421 909CO $$ooai:bib-pubdb1.desy.de:474421$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000474421 9101_ $$0I:(DE-HGF)0$$6P:(DE-H253)PIP1031058$$aExternal Institute$$b5$$kExtern
000474421 9101_ $$0I:(DE-H253)_CSSB-20140311$$6P:(DE-H253)PIP1097669$$aCentre for Structural Systems Biology$$b6$$kCSSB
000474421 9101_ $$0I:(DE-H253)_CSSB-20140311$$6P:(DE-H253)PIP1014042$$aCentre for Structural Systems Biology$$b7$$kCSSB
000474421 9101_ $$0I:(DE-588)1043621512$$6P:(DE-H253)PIP1014042$$aEuropean XFEL$$b7$$kXFEL.EU
000474421 9101_ $$0I:(DE-588b)2008985-5$$6P:(DE-H253)PIP1014042$$aDeutsches Elektronen-Synchrotron$$b7$$kDESY
000474421 9131_ $$0G:(DE-HGF)POF4-633$$1G:(DE-HGF)POF4-630$$2G:(DE-HGF)POF4-600$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bForschungsbereich Materie$$lFrom Matter to Materials and Life$$vLife Sciences – Building Blocks of Life: Structure and Function$$x0
000474421 9141_ $$y2022
000474421 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000474421 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBIOCHEM SOC T : 2019$$d2021-02-04
000474421 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
000474421 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)0400$$2StatID$$aAllianz-Lizenz / DFG$$d2021-02-04$$wger
000474421 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bBIOCHEM SOC T : 2019$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-02-04
000474421 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-02-04
000474421 9201_ $$0I:(DE-H253)FS-CS-20210408$$kFS-CS$$lStrukturelle Mikrobiologie CSSB$$x0
000474421 9201_ $$0I:(DE-H253)U_L__beck-20211012$$kU Lübeck$$lUniversität zu Lübeck$$x1
000474421 9201_ $$0I:(DE-H253)CSSB-LIV_DESY-CU-20220525$$kCSSB-LIV/DESY-CU$$lCSSB - Leibniz-Institut für Experimentelle Virologie (LIV) / DESY - Charlotte Uetrecht$$x2
000474421 980__ $$ajournal
000474421 980__ $$aVDB
000474421 980__ $$aI:(DE-H253)FS-CS-20210408
000474421 980__ $$aI:(DE-H253)U_L__beck-20211012
000474421 980__ $$aI:(DE-H253)CSSB-LIV_DESY-CU-20220525
000474421 980__ $$aUNRESTRICTED
000474421 9801_ $$aFullTexts