% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Osterode:472642,
      author       = {Osterode, Wolf and Falkenberg, Gerald and Wrba, Fritz},
      title        = {{C}opper and {T}race {E}lements in {G}allbladder form
                      {P}atients with {W}ilson’s {D}isease {I}maged and
                      {D}etermined by {S}ynchrotron {X}-ray {F}luorescence},
      journal      = {Journal of imaging},
      volume       = {7},
      number       = {12},
      issn         = {2313-433X},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {PUBDB-2021-05141},
      pages        = {261},
      year         = {2021},
      abstract     = {Investigations about suspected tissue alterations and the
                      role of gallbladder in Wilson’sdisease (WD)—an inherited
                      genetic disease with impaired copper metabolism—are rare.
                      Therefore,tissue from patients with genetically
                      characterised WD was investigated by microscopic
                      synchrotronX-ray fluorescence (SRXRF). For two-dimensional
                      imaging and quantification of elements, X-rayspectra were
                      peak-fitted, and the net peak intensities were normalised to
                      the intensity of the incomingmonochromatic beam intensity.
                      Concentrations were calculated by fundamental
                      parameter-basedprogram quant and external standardisation.
                      Copper (Cu), zinc (Zn) and iron (Fe) along with sulphur(S)
                      and phosphorus (P) mappings could be demonstrated in a near
                      histological resolution. All theseelements were increased
                      compared to gallbladder tissue from controls. Cu and Zn and
                      Fe in WD-GBwere mostly found to be enhanced in the
                      epithelium. We documented a significant linear
                      relationshipwith Cu, Zn and sulphur. Concentrations of Cu/Zn
                      were roughly 1:1 while S/Cu was about 100:1,depending on the
                      selected areas for investigation. The significant linear
                      relationship with Cu, Zn andsulphur let us assume that
                      metallothioneins, which are sulphur-rich proteins, are
                      increased too. Ourdata let us suggest that the WD
                      gallbladder is the first in the gastrointestinal tract to
                      reabsorb metalsto prevent oxidative damage caused by metal
                      toxicity},
      cin          = {FS-PETRA-S},
      ddc          = {004},
      cid          = {I:(DE-H253)FS-PETRA-S-20210408},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633)},
      pid          = {G:(DE-HGF)POF4-633},
      experiment   = {EXP:(DE-H253)D-L-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34940728},
      UT           = {WOS:000738105200001},
      doi          = {10.3390/jimaging7120261},
      url          = {https://bib-pubdb1.desy.de/record/472642},
}