% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Awel:465471,
      author       = {Awel, Salah and Bohne, Sven and Ebrahimifard, Reza and
                      Trieu, Hoc Khiem and Bajt, Sasa and Chapman, Henry N.},
      title        = {{O}ptical bunching of particles in a liquid flow},
      journal      = {Optics express},
      volume       = {29},
      number       = {21},
      issn         = {1094-4087},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {PUBDB-2021-03936},
      pages        = {34394 - 34410},
      year         = {2021},
      abstract     = {High-speed liquid micro-jets are used to rapidly and
                      repeatedly deliver protein microcrystals to focused and
                      pulsed X-ray beams in the method of serial femtosecond
                      crystallography. However, the current continuous flow of
                      crystals is mismatched to the arrival of X-ray pulses,
                      wasting vast amounts of an often rare and precious sample.
                      Here, we introduce a method to address this problem by
                      periodically trapping and releasing crystals in the liquid
                      flow, creating locally concentrated crystal bunches, using
                      an optical trap integrated in the microfluidic supply line.
                      We experimentally demonstrate a 30-fold increase of particle
                      concentration into 10 Hz bunches of 6.4 μm diameter
                      polystyrene particles. Furthermore, using particle
                      trajectory simulations, a comprehensive description of the
                      optical bunching process and parameter space is presented.
                      Adding this compact optofluidics device to existing
                      injection systems would thereby dramatically reduce sample
                      consumption and extend the application of serial
                      crystallography to a greater range of protein crystal
                      systems that cannot be produced in high abundance. Our
                      approach is suitable for other microfluidic systems that
                      require synchronous measurements of flowing objects.},
      cin          = {FS-CFEL-1 / CFEL-XOM / CFEL-I},
      ddc          = {530},
      cid          = {I:(DE-H253)FS-CFEL-1-20120731 /
                      I:(DE-H253)CFEL-XOM-20160915 / I:(DE-H253)CFEL-I-20161114},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / Leibniz Preis - Leibiz Programm
                      2015: Prof. Dr. Henry N. Chapman (DFG-Leibniz-2015-Chapman)
                      / DFG project 390715994 - EXC 2056: CUI: Advanced Imaging of
                      Matter (390715994) / DFG project 194651731 - EXC 1074:
                      Hamburger Zentrum für ultraschnelle Beobachtung (CUI):
                      Struktur, Dynamik und Kontrolle von Materie auf atomarer
                      Skala (194651731) / InternLabs-0011 - HIR3X - Helmholtz
                      International Laboratory on Reliability, Repetition, Results
                      at the most advanced X-ray Sources $(2020_InternLabs-0011)$},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-H253)DFG-Leibniz-2015-Chapman /
                      G:(GEPRIS)390715994 / G:(GEPRIS)194651731 /
                      $G:(DE-HGF)2020_InternLabs-0011$},
      experiment   = {EXP:(DE-H253)CFEL-Exp-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34809231},
      UT           = {WOS:000708940500134},
      doi          = {10.1364/OE.440173},
      url          = {https://bib-pubdb1.desy.de/record/465471},
}