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@ARTICLE{Beckham:465272,
      author       = {Beckham, Katherine S. H. and Ritter, Christina and
                      Chojnowski, Grzegorz Maciej and Ziemianowicz, Daniel and
                      Mullapudi, Edukondalu and Rettel, Mandy and Savitski,
                      Mikhail M. and Mortensen, Simon A. and Kosinski, Jan and
                      Wilmanns, Matthias},
      title        = {{S}tructure of the mycobacterial {ESX}-5 type {VII}
                      secretion system pore complex},
      journal      = {Science advances},
      volume       = {7},
      number       = {26},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {PUBDB-2021-03825},
      pages        = {eabg9923 -},
      year         = {2021},
      abstract     = {The ESX-5 type VII secretion system is a membrane-spanning
                      protein complex key to the virulence of mycobacterial
                      pathogens. However, the overall architecture of the fully
                      assembled translocation machinery and the composition of the
                      central secretion pore have remained unknown. Here, we
                      present the high-resolution structure of the 2.1-megadalton
                      ESX-5 core complex. Our structure captured a dynamic,
                      secretion-competent conformation of the pore within a
                      well-defined transmembrane section, sandwiched between two
                      flexible protein layers at the cytosolic entrance and the
                      periplasmic exit. We propose that this flexibility endows
                      the ESX-5 machinery with large conformational plasticity
                      required to accommodate targeted protein secretion. Compared
                      to known secretion systems, a highly dynamic state of the
                      pore may represent a fundamental principle of bacterial
                      secretion machineries.},
      cin          = {EMBL / CSSB-EMBL / EMBL-User / CSSB-EMBL-JK},
      ddc          = {500},
      cid          = {I:(DE-H253)EMBL-20120731 / I:(DE-H253)CSSB-EMBL-20141216 /
                      I:(DE-H253)EMBL-User-20120814 /
                      I:(DE-H253)CSSB-EMBL-JK-20210701},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P13-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34172453},
      UT           = {WOS:000669960200018},
      doi          = {10.1126/sciadv.abg9923},
      url          = {https://bib-pubdb1.desy.de/record/465272},
}