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@ARTICLE{Ishak:461989,
      author       = {Ishak, Mohd I. and Jenkins, Joshua and Kulkarni,
                      Satishkumar and Keller, Thomas F. and Briscoe, Wuge and
                      Nobbs, Angela H. and Su, Bo},
      title        = {{I}nsights into complex nanopillar-bacteria interactions:
                      {R}oles of nanotopography and bacterial surface proteins},
      journal      = {Journal of colloid and interface science},
      volume       = {604},
      issn         = {0021-9797},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {PUBDB-2021-03218},
      pages        = {91 - 103},
      year         = {2021},
      abstract     = {Nanopillared surfaces have emerged as a promising strategy
                      to combat bacterial infections on medicaldevices. However,
                      the mechanisms that underpin nanopillar-induced rupture of
                      the bacterial cell membraneremain speculative. In this
                      study, we have tested three medically relevant poly(ethylene
                      terephthalate)(PET) nanopillared-surfaces with well-defined
                      nanotopographies against both Gram-negative andGram-positive
                      bacteria. Focused ion beam scanning electron microscopy
                      (FIB-SEM) and contact mechanicsanalysis were utilised to
                      understand the nanobiophysical response of the bacterial
                      cell envelope to asingle nanopillar. Given their importance
                      to bacterial adhesion, the contribution of bacterial surface
                      proteinsto nanotopography-mediated cell envelope damage was
                      also investigated. We found that, whilstcell envelope
                      deformation was affected by the nanopillar tip diameter, the
                      nanopillar density affectedbacterial metabolic activities.
                      Moreover, three different types of bacterial cell envelope
                      deformation wereobserved upon contact of bacteria with the
                      nanopillared surfaces. These were attributed to
                      bacterialresponses to cell wall stresses resulting from the
                      high intrinsic pressure caused by the engagement
                      ofnanopillars by bacterial surface proteins. Such influences
                      of bacterial surface proteins on the antibacterial action of
                      nanopillars have not been previously reported. Our findings
                      will be valuable to the improveddesign and fabrication of
                      effective antibacterial surfaces.},
      cin          = {FS-PS / FS-NL},
      ddc          = {540},
      cid          = {I:(DE-H253)FS-PS-20131107 / I:(DE-H253)FS-NL-20120731},
      pnm          = {632 - Materials – Quantum, Complex and Functional
                      Materials (POF4-632) / $NFFA-Europe_supported$ - Technically
                      supported by Nanoscience Foundries and Fine Analysis Europe
                      $(2020_Join2-NFFA-Europe_funded)$},
      pid          = {G:(DE-HGF)POF4-632 /
                      $G:(DE-HGF)2020_Join2-NFFA-Europe_funded$},
      experiment   = {EXP:(DE-H253)Nanolab-01-20150101 /
                      EXP:(DE-H253)Nanolab-04-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34265695},
      UT           = {WOS:000703521300004},
      doi          = {10.1016/j.jcis.2021.06.173},
      url          = {https://bib-pubdb1.desy.de/record/461989},
}