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000461989 1001_ $$0P:(DE-HGF)0$$aIshak, Mohd I.$$b0
000461989 245__ $$aInsights into complex nanopillar-bacteria interactions: Roles of nanotopography and bacterial surface proteins
000461989 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2021
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000461989 520__ $$aNanopillared surfaces have emerged as a promising strategy to combat bacterial infections on medicaldevices. However, the mechanisms that underpin nanopillar-induced rupture of the bacterial cell membraneremain speculative. In this study, we have tested three medically relevant poly(ethylene terephthalate)(PET) nanopillared-surfaces with well-defined nanotopographies against both Gram-negative andGram-positive bacteria. Focused ion beam scanning electron microscopy (FIB-SEM) and contact mechanicsanalysis were utilised to understand the nanobiophysical response of the bacterial cell envelope to asingle nanopillar. Given their importance to bacterial adhesion, the contribution of bacterial surface proteinsto nanotopography-mediated cell envelope damage was also investigated. We found that, whilstcell envelope deformation was affected by the nanopillar tip diameter, the nanopillar density affectedbacterial metabolic activities. Moreover, three different types of bacterial cell envelope deformation wereobserved upon contact of bacteria with the nanopillared surfaces. These were attributed to bacterialresponses to cell wall stresses resulting from the high intrinsic pressure caused by the engagement ofnanopillars by bacterial surface proteins. Such influences of bacterial surface proteins on the antibacterial action of nanopillars have not been previously reported. Our findings will be valuable to the improveddesign and fabrication of effective antibacterial surfaces.
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000461989 693__ $$0EXP:(DE-H253)Nanolab-04-20150101$$1EXP:(DE-H253)DESY-NanoLab-20150101$$5EXP:(DE-H253)Nanolab-04-20150101$$aNanolab$$eDESY NanoLab: Microscopy$$x1
000461989 7001_ $$0P:(DE-H253)PIP1085257$$aJenkins, Joshua$$b1
000461989 7001_ $$0P:(DE-H253)PIP1025923$$aKulkarni, Satishkumar$$b2$$udesy
000461989 7001_ $$0P:(DE-H253)PIP1019138$$aKeller, Thomas F.$$b3$$udesy
000461989 7001_ $$0P:(DE-H253)PIP1083619$$aBriscoe, Wuge$$b4
000461989 7001_ $$0P:(DE-HGF)0$$aNobbs, Angela H.$$b5
000461989 7001_ $$0P:(DE-H253)PIP1084166$$aSu, Bo$$b6$$eCorresponding author
000461989 773__ $$0PERI:(DE-600)1469021-4$$a10.1016/j.jcis.2021.06.173$$gVol. 604, p. 91 - 103$$p91 - 103$$tJournal of colloid and interface science$$v604$$x0021-9797$$y2021
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