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@ARTICLE{Stockhausen:457014,
      author       = {Stockhausen, Kilian E. and Qwamizadeh, Mahan and Wölfel,
                      Eva M. and Hemmatian, Haniyeh and Fiedler, Imke A. K. and
                      Flenner, Silja and Longo, Elena and Amling, Michael and
                      Greving, Imke and Ritchie, Robert O. and Schmidt, Felix N.
                      and Busse, Björn},
      title        = {{C}ollagen {F}iber {O}rientation {I}s {C}oupled with
                      {S}pecific {N}ano-{C}ompositional {P}atterns in {D}ark and
                      {B}right {O}steons {M}odulating {T}heir {B}iomechanical
                      {P}roperties},
      journal      = {ACS nano},
      volume       = {15},
      number       = {1},
      issn         = {1936-086X},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {PUBDB-2021-01801},
      pages        = {455 - 467},
      year         = {2021},
      abstract     = {Bone continuously adapts to its mechanical environment by
                      structural reorganization to maintain mechanical strength.
                      As the adaptive capabilities of bone are portrayed in its
                      nano- and microstructure, the existence of dark and bright
                      osteons with contrasting preferential collagen fiber
                      orientation (longitudinal and oblique-angled, respectively)
                      points at a required tissue heterogeneity that contributes
                      to the excellent fracture resistance mechanisms in bone.
                      Dark and bright osteons provide an exceptional opportunity
                      to deepen our understanding of how nanoscale tissue
                      properties influence and guide fracture mechanisms at larger
                      length scales. To this end, a comprehensive structural,
                      compositional, and mechanical assessment is performed using
                      circularly polarized light microscopy, synchrotron
                      nanocomputed tomography, focused ion beam/scanning electron
                      microscopy, quantitative backscattered electron imaging,
                      Fourier transform infrared spectroscopy, and nanoindentation
                      testing. To predict how the mechanical behavior of osteons
                      is affected by shifts in collagen fiber orientation, finite
                      element models are generated. Fundamental disparities
                      between both osteon types are observed: dark osteons are
                      characterized by a higher degree of mineralization along
                      with a higher ratio of inorganic to organic matrix
                      components that lead to higher stiffness and the ability to
                      resist plastic deformation under compression. On the
                      contrary, bright osteons contain a higher fraction of
                      collagen and provide enhanced ductility and energy
                      dissipation due to lower stiffness and hardness.},
      cin          = {HZG / DOOR ; HAS-User},
      ddc          = {540},
      cid          = {I:(DE-H253)HZG-20120731 / I:(DE-H253)HAS-User-20120731},
      pnm          = {6G3 - PETRA III (DESY) (POF4-6G3)},
      pid          = {G:(DE-HGF)POF4-6G3},
      experiment   = {EXP:(DE-H253)P-P05-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33404232},
      UT           = {WOS:000613942700028},
      doi          = {10.1021/acsnano.0c04786},
      url          = {https://bib-pubdb1.desy.de/record/457014},
}