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@ARTICLE{Drner:456627,
author = {Dörner, Simon and Schwob, Lucas and Schubert, Kaja and
Girod, Marion and MacAleese, Luke and Pieterse, Cornelius
Louwrens and Schlathoelter, Thomas and Techert, Simone and
Bari, Sadia},
title = {{T}he influence of the methionine residue on the
dissociation mechanisms of photoionized
methionine-enkephalin probed by {VUV} action spectroscopy},
journal = {The European physical journal / D},
volume = {75},
number = {4},
issn = {1434-6060},
address = {Heidelberg},
publisher = {Springer},
reportid = {PUBDB-2021-01567},
pages = {142},
year = {2021},
abstract = {VUV action spectroscopy has recently gained interest for
the study of peptides and proteins. However, numerous
aspects of the fundamental processes involved in the
photodissociation are yet to be understood. It can, for
example, be expected that sulfur-containing amino-acid
residues have a significant impact on the dissociation
processes following photoionization because of their
potential involvement in the transport of electron holes in
proteins. In order to investigate the influence of the
sulfur-containing methionine residue on the VUV
photodissociation of a small peptide a VUV action
spectroscopy study of gas-phase protonated
methionine-enkephalin and leucine-enkephalin in the photon
energy range of 6–35 eV was performed. The results show
that upon non-ionizing photoexcitation, the fragmentation
patterns of the two peptides are nearly identical, whereas
significant differences were observed upon photoionization.
The differences between the fragment yields and the
identified specific dissociation channels for
methionineenkephalin could be explained by the high electron
hole affinity of sulfur, which efficiently directs the
radical to the methionine side chain. Additionally, for both
peptides the presence of the intact photoionized precursor
ions was confirmed by their isotopic patterns and the
stability of these species could be evaluated.},
cin = {FS-SCS},
ddc = {530},
cid = {I:(DE-H253)FS-SCS-20131031},
pnm = {633 - Life Sciences – Building Blocks of Life: Structure
and Function (POF4-633) / VH-NG-1104 - Structure and
dynamics of gas-phase biomolecules studied by photon-induced
ionization and dissociation $(2007_IVF-VH-NG-1104)$ / DFG
project 28586557 - SFB 755: Photonische Abbildungen auf der
Nanometerskala (28586557)},
pid = {G:(DE-HGF)POF4-633 / $G:(DE-HGF)2007_IVF-VH-NG-1104$ /
G:(GEPRIS)28586557},
experiment = {EXP:(DE-MLZ)External-20140101},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000733023100003},
doi = {10.1140/epjd/s10053-021-00147-y},
url = {https://bib-pubdb1.desy.de/record/456627},
}