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@ARTICLE{Pazicky:449860,
      author       = {Pazicky, Samuel and Dhamotharan, Karthikeyan and Kaszuba,
                      Karol and Mertens, Haydyn D. T. and Gilberger, Tim and
                      Svergun, Dmitri and Kosinski, Jan and Weininger, Ulrich and
                      Loew, Christian},
      title        = {{S}tructural role of essential light chains in the
                      apicomplexan glideosome},
      journal      = {Communications biology},
      volume       = {3},
      number       = {1},
      issn         = {2399-3642},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {PUBDB-2020-04058},
      pages        = {568},
      year         = {2020},
      note         = {PIF-2018-87},
      abstract     = {Gliding, a type of motility based on an actin-myosin motor,
                      is specific to apicomplexan parasites. Myosin A binds two
                      light chains which further interact with glideosome
                      associated proteins and assemble into the glideosome. The
                      role of individual glideosome proteins is unclear due to the
                      lack of structures of larger glideosome assemblies. Here, we
                      investigate the role of essential light chains (ELCs) in
                      Toxoplasma gondii and Plasmodium falciparum and present
                      their crystal structures as part of trimeric sub-complexes.
                      We show that although ELCs bind a conserved MyoA sequence,
                      P. falciparum ELC adopts a distinct structure in the free
                      and MyoA-bound state. We suggest that ELCs enhance MyoA
                      performance by inducing secondary structure in MyoA and thus
                      stiffen its lever arm. Structural and biophysical analysis
                      reveals that calcium binding has no influence on the
                      structure of ELCs. Our work represents a further step
                      towards understanding the mechanism of gliding in
                      Apicomplexa.},
      cin          = {EMBL / EMBL-User / CSSB-EMBL-CL / CSSB-EMBL-JK /
                      CSSB-BNITM-TG},
      ddc          = {570},
      cid          = {I:(DE-H253)EMBL-20120731 / I:(DE-H253)EMBL-User-20120814 /
                      I:(DE-H253)CSSB-EMBL-CL-20210806 /
                      I:(DE-H253)CSSB-EMBL-JK-20210701 /
                      I:(DE-H253)CSSB-BNITM-TG-20210520},
      pnm          = {6G3 - PETRA III (POF3-622)},
      pid          = {G:(DE-HGF)POF3-6G3},
      experiment   = {EXP:(DE-H253)P-P12-20150101 / EXP:(DE-H253)P-P13-20150101 /
                      EXP:(DE-H253)P-P14-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33051581},
      UT           = {WOS:000583301900001},
      doi          = {10.1038/s42003-020-01283-8},
      url          = {https://bib-pubdb1.desy.de/record/449860},
}