TY - JOUR AU - Sobolev, Egor AU - Zolotarev, Sergei AU - Giewekemeyer, Klaus AU - Bielecki, Johan AU - Okamoto, Kenta AU - Reddy, Hemanth K. N. AU - Andreasson, Jakob AU - Ayyer, Kartik AU - Barak, Imrich AU - Bari, Sadia AU - Barty, Anton AU - Bean, Richard AU - Bobkov, Sergey AU - Chapman, Henry N. AU - Chojnowski, Grzegorz AU - Daurer, Benedikt AU - Dörner, Katerina AU - Ekeberg, Tomas AU - Flückiger, Leonie AU - Galzitskaya, Oxana AU - Gelisio, Luca AU - Hauf, Steffen AU - Hogue, Brenda G. AU - Horke, Daniel A. AU - Hosseinizadeh, Ahmad AU - Ilyin, Vyacheslav AU - Jung, Chulho AU - Kim, Chan AU - Kim, Yoonhee AU - Kirian, Richard A. AU - Kirkwood, Henry AU - Kulyk, Olena AU - Küpper, Jochen AU - Letrun, Romain AU - Loh, N. Duane AU - Lorenzen, Kristina AU - Messerschmidt, Marc AU - Mühlig, Kerstin AU - Ourmazd, Abbas AU - Raab, Natascha AU - Rode, Andrei V. AU - Rose, Max AU - Round, Adam AU - Sato, Takushi AU - Schubert, Robin AU - Schwander, Peter AU - Sellberg, Jonas AU - Sikorski, Marcin AU - Silenzi, Alessandro AU - Song, Changyong AU - Spence, John C. H. AU - Stern, Stephan AU - Sztuk-Dambietz, Jolanta AU - Teslyuk, Anthon AU - Timneanu, Nicusor AU - Trebbin, Martin AU - Uetrecht, Charlotte AU - Weinhausen, Britta AU - Williams, Garth J. AU - Xavier, P. Lourdu AU - Xu, Chen AU - Vartanyants, Ivan A. AU - Lamzin, Victor S. AU - Mancuso, Adrian AU - Maia, Filipe R. N. C. TI - Megahertz single-particle imaging at the European XFEL JO - Communications Physics VL - 3 IS - 1 SN - 2399-3650 CY - London PB - Springer Nature M1 - PUBDB-2020-02231 M1 - arXiv:1912.10796 SP - 97 PY - 2020 N1 - Open access AB - The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL is expected to provide 27,000 pulses per second, over two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The results obtained pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate. LB - PUB:(DE-HGF)16 UR - <Go to ISI:>//WOS:000553489000001 DO - DOI:10.1038/s42005-020-0362-y UR - https://bib-pubdb1.desy.de/record/440898 ER -