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@ARTICLE{Nicolas:420674,
      author       = {Nicolas, Jan-David and Bernhardt, Marten and Schlick,
                      Susanne F. and Tiburcy, Malte and Zimmermann,
                      Wolfram-Hubertus and Khan, Amara and Markus, Andrea and
                      Alves, Frauke and Toischer, Karl and Salditt, Tim},
      title        = {{X}-ray diffraction imaging of cardiac cells and tissue},
      journal      = {Progress in biophysics $\&$ molecular biology},
      volume       = {144},
      issn         = {0079-6107},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PUBDB-2019-01625},
      pages        = {151 - 165},
      year         = {2019},
      abstract     = {With the development of advanced focusing optics for
                      x-rays, we can now use x-ray beams with spot sizes in the
                      micro- or nanometer range to scan cells and large areas of
                      tissues and continuously record the diffraction signals.
                      From this data, x-ray scattering maps or so-called x-ray
                      darkfield images are computed showing how different types of
                      cells or regions of tissues differ in their diffraction
                      intensity. At the same time a diffraction pattern is
                      available for each scan point which encodes the local
                      nanostructure, averaged over many contributing constituents
                      illuminated by the beam. In this work we have exploited
                      these new capabilities of scanning x-ray diffraction to
                      investigate cardiac muscle cells as well as cardiac tissue.
                      We give examples of how cardiac cells, especially living,
                      cultured cells, can be prepared to be compatible with the
                      instrumentation constraints of nano- or micro-diffraction
                      instruments. Furthermore, we show how the developmental
                      stage, ranging from neonatal to adult cells, as well as the
                      final preparation state of the cardiomyocytes influences the
                      recorded scattering signal and how these diffraction signals
                      compare to the structure of a fully developed cardiac
                      muscle.},
      cin          = {DOOR},
      ddc          = {570},
      cid          = {I:(DE-H253)HAS-User-20120731},
      pnm          = {6G3 - PETRA III (POF3-622)},
      pid          = {G:(DE-HGF)POF3-6G3},
      experiment   = {EXP:(DE-H253)P-P10-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29914693},
      UT           = {WOS:000472812100014},
      doi          = {10.1016/j.pbiomolbio.2018.05.012},
      url          = {https://bib-pubdb1.desy.de/record/420674},
}