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@ARTICLE{Kooshapur:417862,
      author       = {Kooshapur, Hamed and Choudhury, Nila Roy and Simon, Bernd
                      and Mühlbauer, Max and Jussupow, Alexander and Fernandez,
                      Noemi and Jones, Alisha N. and Dallmann, Andre and Gabel,
                      Frank and Camilloni, Carlo and Michlewski, Gracjan and
                      Caceres, Javier F. and Sattler, Michael},
      title        = {{S}tructural basis for terminal loop recognition and
                      stimulation of pri-mi{RNA}-18a processing by hn{RNP} {A}1},
      journal      = {Nature Communications},
      volume       = {9},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publ. Group},
      reportid     = {PUBDB-2019-00038},
      pages        = {2479},
      year         = {2018},
      abstract     = {Post-transcriptional mechanisms play a predominant role in
                      the control of microRNA (miRNA) production. Recognition of
                      the terminal loop of precursor miRNAs by RNA-binding
                      proteins (RBPs) influences their processing; however, the
                      mechanistic basis for how levels of individual or subsets of
                      miRNAs are regulated is mostly unexplored. We previously
                      showed that hnRNP A1, an RBP implicated in many aspects of
                      RNA processing, acts as an auxiliary factor that promotes
                      the Microprocessor-mediated processing of pri-mir-18a. Here,
                      by using an integrative structural biology approach, we show
                      that hnRNP A1 forms a 1:1 complex with pri-mir-18a where
                      both RNA recognition motifs (RRMs) bind to cognate RNA
                      sequence motifs in the terminal loop of pri-mir-18a.
                      Terminal loop binding induces an allosteric destabilization
                      of base-pairing in the pri-mir-18a stem that promotes its
                      downstream processing. Our results highlight terminal loop
                      RNA recognition by RBPs as a potential general principle of
                      miRNA biogenesis and regulation.},
      cin          = {EMBL-User},
      ddc          = {500},
      cid          = {I:(DE-H253)EMBL-User-20120814},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      experiment   = {EXP:(DE-H253)D-D1.2-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29946118},
      UT           = {WOS:000436236800007},
      doi          = {10.1038/s41467-018-04871-9},
      url          = {https://bib-pubdb1.desy.de/record/417862},
}