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@ARTICLE{Aleksandrova:417861,
      author       = {Aleksandrova, Nataliia and Gutsche, Irina and Kandiah,
                      Eaazhisai and Avilov, Sergiy V. and Petoukhov, Maxim V. and
                      Seiradake, Elena and McCarthy, Andrew A.},
      title        = {{R}obo1 {F}orms a {C}ompact {D}imer-of-{D}imers {A}ssembly},
      journal      = {Structure},
      volume       = {26},
      number       = {2},
      issn         = {0969-2126},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {PUBDB-2019-00037},
      pages        = {320 - 328},
      year         = {2018},
      abstract     = {Roundabout (Robo) receptors provide an essential repulsive
                      cue in neuronal development following Slit ligand binding.
                      This important signaling pathway can also be hijacked in
                      numerous cancers, making Slit-Robo an attractive therapeutic
                      target. However, little is known about how Slit binding
                      mediates Robo activation. Here we present the crystal
                      structure of Robo1 Ig1-4 and Robo1 Ig5, together with a
                      negative stain electron microscopy reconstruction of the
                      Robo1 ectodomain. These results show how the Robo1
                      ectodomain is arranged as compact dimers, mainly mediated by
                      the central Ig domains, which can further interact in a
                      “back-to-back” fashion to generate a tetrameric
                      assembly. We also observed no change in Robo1
                      oligomerization upon interaction with the dimeric Slit2-N
                      ligand using fluorescent imaging. Taken together with
                      previous studies we propose that Slit2-N binding results in
                      a conformational change of Robo1 to trigger cell signaling.},
      cin          = {EMBL-User / EMBL},
      ddc          = {540},
      cid          = {I:(DE-H253)EMBL-User-20120814 / I:(DE-H253)EMBL-20120731},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      experiment   = {EXP:(DE-H253)D-D1.2-20150101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29307485},
      UT           = {WOS:000424806800015},
      doi          = {10.1016/j.str.2017.12.003},
      url          = {https://bib-pubdb1.desy.de/record/417861},
}