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| 001 | 414312 | ||
| 005 | 20250717101509.0 | ||
| 024 | 7 | _ | |a 10.1016/j.jtemb.2018.09.007 |2 doi |
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| 100 | 1 | _ | |a Osterode, W. |0 P:(DE-H253)PIP1008430 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Quantitative trace element mapping in liver tissue from patients with Wilson`s disease determined by micro X-ray fluorescence |
| 260 | _ | _ | |a München |c 2019 |b Elsevier |
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| 520 | _ | _ | |a Aims: of this investigation were to quantify copper (Cu), iron (Fe) and zinc (Zn) along with sulphur (S) andphosphorus (P) in hepatocytes and connective tissue in liver section from patients with Wilson´s disease (WD) bymicro Synchrotron X-ray fluorescence (μ-SRXRF). Secondly to establish two-dimensional μ-SRXRF elementmappings for comparison with histologically prepared slices, and thirdly to assess whether elemental distribu-tions are associated.Methods: Archival liver tissues from twelve patients with end-stage cirrhosis or fulminant WD were investigated.Mutations in ATP7B have been classified before. For control seven archived normal liver tissues were in-vestigated. μ-SRXRF measurements were performed at the DORIS III storage ring at HASYLAB/DESY (Hamburg,Germany). Two-dimensional element distribution were compared with histologically prepared slices about20–30 μm apart from those investigated by μ-SRXRF.Results: Elementary copper (Cu) could be demonstrated in all investigated liver sections simultaneously with Fe,Zn, P and S. In WD mean Cu was 20 fold increased in hepatocytes and threefold in fibrotic areas in comparisonwith controls. In regeneration nodules Cu was strikingly inhomogeneous distributed. Cu concentrations mea-sured by μ-SRXRF correlated with those measured by atom absorption spectroscopy. Strong associations in theirregional distribution existed between Zn and Cu or Fe and S. Moreover, differences in Cu/S were found betweenhepatocytes and fibrotic areas. An increase of Fe could only be documented in hepatocytes compared to fibroticareas. With a beam size of 15 x 15 μm two-dimensional distributions of these elements are morphologicallycomparable with histological section with a magnification of about 25x optic microscope.Conclusions: μ-SRXRF investigations are a valuable tool for quantifying element concentrations in biologicaltissues and further provide 2-dimensional information of element distribution and elemental association in abiological tissues, thus speeding up basic knowledge in a synopsis with biological and clinical data. |
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| 773 | _ | _ | |a 10.1016/j.jtemb.2018.09.007 |g Vol. 51, p. 42 - 49 |0 PERI:(DE-600)2174174-8 |p 42 - 49 |t Journal of trace elements in medicine and biology |v 51 |y 2019 |x 0946-672X |
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