000397870 001__ 397870
000397870 005__ 20250730104502.0
000397870 0247_ $$2doi$$a10.1002/chem.201701591
000397870 0247_ $$2ISSN$$a0947-6539
000397870 0247_ $$2ISSN$$a1521-3765
000397870 0247_ $$2pmid$$apmid:28493496
000397870 0247_ $$2WOS$$aWOS:000404550000003
000397870 0247_ $$2altmetric$$aaltmetric:45920044
000397870 0247_ $$2openalex$$aopenalex:W2612339432
000397870 037__ $$aPUBDB-2017-13502
000397870 041__ $$aEnglish
000397870 082__ $$a540
000397870 1001_ $$00000-0002-7671-6887$$aMamais, Michael$$b0
000397870 245__ $$aA New Potent Inhibitor of Glycogen Phosphorylase Reveals the Basicity of the Catalytic Site
000397870 260__ $$aWeinheim$$bWiley-VCH$$c2017
000397870 3367_ $$2DRIVER$$aarticle
000397870 3367_ $$2DataCite$$aOutput Types/Journal article
000397870 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1571669879_16867
000397870 3367_ $$2BibTeX$$aARTICLE
000397870 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000397870 3367_ $$00$$2EndNote$$aJournal Article
000397870 500__ $$a© Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim ; Post referee fulltext in progress; Embargo 12 months from publication
000397870 520__ $$aThe design and synthesis of a glucose-based acridone derivative (GLAC), a potent inhibitor of glycogen phosphorylase (GP) are described. GLAC is the first inhibitor of glycogen phosphorylase, the electronic absorption properties of which are clearly distinguishable from those of the enzyme. This allows probing subtle interactions in the catalytic site. The GLAC absorption spectra, associated with X-ray crystallography and quantum chemistry calculations, reveal that part of the catalytic site of GP behaves as a highly basic environment in which GLAC exists as a bis-anion. This is explained by water-bridged hydrogen-bonding interactions with specific catalytic site residues.
000397870 536__ $$0G:(DE-HGF)POF3-6G3$$a6G3 - PETRA III (POF3-622)$$cPOF3-622$$fPOF III$$x0
000397870 536__ $$0G:(EU-Grant)283570$$aBIOSTRUCT-X - Transnational access and enhancement of integrated Biological Structure determination at synchrotron X-ray radiation facilities (283570)$$c283570$$fFP7-INFRASTRUCTURES-2011-1$$x1
000397870 536__ $$0G:(EU-Grant)284464$$aLASERLAB-EUROPE - The Integrated Initiative of European Laser Research Infrastructures III (284464)$$c284464$$fFP7-INFRASTRUCTURES-2011-1$$x2
000397870 588__ $$aDataset connected to CrossRef
000397870 693__ $$0EXP:(DE-H253)P-P14-20150101$$1EXP:(DE-H253)PETRAIII-20150101$$6EXP:(DE-H253)P-P14-20150101$$aPETRA III$$fPETRA Beamline P14$$x0
000397870 7001_ $$00000-0002-3594-2669$$aDegliEsposti, Alessandra$$b1
000397870 7001_ $$aKouloumoundra, Virginia$$b2
000397870 7001_ $$00000-0001-7030-6812$$aGustavsson, Thomas$$b3
000397870 7001_ $$00000-0002-9806-1957$$aMonti, Filippo$$b4
000397870 7001_ $$00000-0002-9496-3910$$aVenturini, Alessandro$$b5$$eCorresponding author
000397870 7001_ $$00000-0001-8147-9030$$aChrysina, Evangelia D.$$b6
000397870 7001_ $$00000-0002-2726-305X$$aMarkovitsi, Dimitra$$b7
000397870 7001_ $$00000-0003-1408-2505$$aGimisis, Thanasis$$b8
000397870 773__ $$0PERI:(DE-600)1478547-x$$a10.1002/chem.201701591$$gVol. 23, no. 37, p. 8800 - 8805$$n37$$p8800 - 8805$$tChemistry - a European journal$$v23$$x0947-6539$$y2017
000397870 8564_ $$uhttps://bib-pubdb1.desy.de/record/397870/files/Mamais_et_al-2017-Chemistry_-_A_European_Journal.pdf$$yRestricted
000397870 8564_ $$uhttps://bib-pubdb1.desy.de/record/397870/files/Mamais_et_al-2017-Chemistry_-_A_European_Journal.gif?subformat=icon$$xicon$$yRestricted
000397870 8564_ $$uhttps://bib-pubdb1.desy.de/record/397870/files/Mamais_et_al-2017-Chemistry_-_A_European_Journal.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000397870 8564_ $$uhttps://bib-pubdb1.desy.de/record/397870/files/Mamais_et_al-2017-Chemistry_-_A_European_Journal.jpg?subformat=icon-180$$xicon-180$$yRestricted
000397870 8564_ $$uhttps://bib-pubdb1.desy.de/record/397870/files/Mamais_et_al-2017-Chemistry_-_A_European_Journal.jpg?subformat=icon-640$$xicon-640$$yRestricted
000397870 8564_ $$uhttps://bib-pubdb1.desy.de/record/397870/files/Mamais_et_al-2017-Chemistry_-_A_European_Journal.pdf?subformat=pdfa$$xpdfa$$yRestricted
000397870 909CO $$ooai:bib-pubdb1.desy.de:397870$$pec_fundedresources$$pVDB$$popenaire
000397870 9131_ $$0G:(DE-HGF)POF3-622$$1G:(DE-HGF)POF3-620$$2G:(DE-HGF)POF3-600$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF3-6G3$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vFacility topic: Research on Matter with Brilliant Light Sources$$x0
000397870 9141_ $$y2017
000397870 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000397870 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000397870 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000397870 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000397870 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCHEM-EUR J : 2015
000397870 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000397870 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000397870 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000397870 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000397870 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences
000397870 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCHEM-EUR J : 2015
000397870 9201_ $$0I:(DE-H253)EMBL-User-20120814$$kEMBL-User$$lEMBL-User$$x0
000397870 980__ $$ajournal
000397870 980__ $$aVDB
000397870 980__ $$aI:(DE-H253)EMBL-User-20120814
000397870 980__ $$aUNRESTRICTED