Home > Publications database > Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5 > print

001     317044
005     20250730111800.0
024 7 _ |a 10.1016/j.jsb.2016.01.014
|2 doi
024 7 _ |a 1047-8477
|2 ISSN
024 7 _ |a 1095-8657
|2 ISSN
024 7 _ |a WOS:000371193600008
|2 WOS
024 7 _ |a 10.3204/PUBDB-2017-00385
|2 datacite_doi
024 7 _ |a pmid:26828112
|2 pmid
024 7 _ |a altmetric:10344468
|2 altmetric
024 7 _ |a openalex:W2273849901
|2 openalex
037 _ _ |a PUBDB-2017-00385
041 _ _ |a English
082 _ _ |a 540
100 1 _ |a Brandenburg, Klaus
|0 P:(DE-HGF)0
|b 0
|e Corresponding author
245 _ _ |a Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5
260 _ _ |a San Diego, Calif.
|c 2016
|b Elsevier
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1508848790_15305
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
500 _ _ |a © Elsevier Inc
520 _ _ |a Lipopolysaccharides (LPS) belong to the strongest immune-modulating compounds known in nature, and are often described as pathogen-associated molecular patterns (PAMPs). In particular, at higher concentrations they are responsible for sepsis and the septic shock syndrome associated with high lethality. Since most data are indicative that LPS aggregates are the bioactive units, their supramolecular structures are considered to be of outmost relevance for deciphering the molecular mechanisms of its bioactivity. So far, however, most of the data available addressing this issue, were published only for the lipid part (lipid A) and the core-oligosaccharide containing rough LPS, representing the bioactive unit. By contrast, it is well known that most of the LPS specimen identified in natural habitats contain the smooth-form (S-form) LPS, which carry additionally a high-molecular polysaccharide (O-chain). To fill this lacuna and going into a more natural system, here various wild-type (smooth form) LPS including also some LPS fractions were investigated by small-angle X-ray scattering with synchrotron radiation to analyze their aggregate structure. Furthermore, the influence of a recently designed synthetic anti-LPS peptide (SALP) Pep19-2.5 on the aggregate structure, on the binding thermodynamics, and on the cytokine-inducing activity of LPS were characterized, showing defined aggregate changes, high affinity binding and inhibition of cytokine secretion. The data obtained are suitable to refine our view on the preferences of LPS for non-lamellar structures, representing the highest bioactive forms which can be significantly influenced by the binding with neutralizing peptides such as Pep19-2.5.
536 _ _ |a 899 - ohne Topic (POF3-899)
|0 G:(DE-HGF)POF3-899
|c POF3-899
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef
693 _ _ |a DORIS III
|e Facility (machine) DORIS III
|1 EXP:(DE-H253)DORISIII-20150101
|0 EXP:(DE-H253)DORISIII(machine)-20150101
|5 EXP:(DE-H253)DORISIII(machine)-20150101
|x 0
700 1 _ |a Heinbockel, Lena
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Correa, Wilmar
|0 P:(DE-HGF)0
|b 2
700 1 _ |a Fukuoka, Satoshi
|0 P:(DE-HGF)0
|b 3
700 1 _ |a Gutsmann, Thomas
|0 P:(DE-H253)PIP1013892
|b 4
700 1 _ |a Zähringer, Ulrich
|0 P:(DE-HGF)0
|b 5
700 1 _ |a Koch, Michel H. J.
|0 P:(DE-HGF)0
|b 6
773 _ _ |a 10.1016/j.jsb.2016.01.014
|g Vol. 194, no. 1, p. 68 - 77
|0 PERI:(DE-600)1469822-5
|n 1
|p 68 - 77
|t Journal of structural biology
|v 194
|y 2016
|x 1047-8477
856 4 _ |y Published on 2016-01-29. Available in OpenAccess from 2017-01-29.
|z StatID:(DE-HGF)0510
|u https://bib-pubdb1.desy.de/record/317044/files/SupramolecularStructureRevidierteversion.pdf
856 4 _ |y Restricted
|z StatID:(DE-HGF)0599
|u https://bib-pubdb1.desy.de/record/317044/files/10.1016_j.jsb.2016.01.014.pdf
856 4 _ |y Restricted
|x icon
|z StatID:(DE-HGF)0599
|u https://bib-pubdb1.desy.de/record/317044/files/10.1016_j.jsb.2016.01.014.gif?subformat=icon
856 4 _ |y Restricted
|x icon-1440
|z StatID:(DE-HGF)0599
|u https://bib-pubdb1.desy.de/record/317044/files/10.1016_j.jsb.2016.01.014.jpg?subformat=icon-1440
856 4 _ |y Restricted
|x icon-180
|z StatID:(DE-HGF)0599
|u https://bib-pubdb1.desy.de/record/317044/files/10.1016_j.jsb.2016.01.014.jpg?subformat=icon-180
856 4 _ |y Restricted
|x icon-640
|z StatID:(DE-HGF)0599
|u https://bib-pubdb1.desy.de/record/317044/files/10.1016_j.jsb.2016.01.014.jpg?subformat=icon-640
856 4 _ |u https://bib-pubdb1.desy.de/record/317044/files/SupramolecularStructureRevidierteversion.gif?subformat=icon
|x icon
|y Published on 2016-01-29. Available in OpenAccess from 2017-01-29.
|z StatID:(DE-HGF)0510
856 4 _ |u https://bib-pubdb1.desy.de/record/317044/files/SupramolecularStructureRevidierteversion.jpg?subformat=icon-1440
|x icon-1440
|y Published on 2016-01-29. Available in OpenAccess from 2017-01-29.
|z StatID:(DE-HGF)0510
856 4 _ |u https://bib-pubdb1.desy.de/record/317044/files/SupramolecularStructureRevidierteversion.jpg?subformat=icon-180
|x icon-180
|y Published on 2016-01-29. Available in OpenAccess from 2017-01-29.
|z StatID:(DE-HGF)0510
856 4 _ |u https://bib-pubdb1.desy.de/record/317044/files/SupramolecularStructureRevidierteversion.jpg?subformat=icon-640
|x icon-640
|y Published on 2016-01-29. Available in OpenAccess from 2017-01-29.
|z StatID:(DE-HGF)0510
856 4 _ |u https://bib-pubdb1.desy.de/record/317044/files/SupramolecularStructureRevidierteversion.pdf?subformat=pdfa
|x pdfa
|y Published on 2016-01-29. Available in OpenAccess from 2017-01-29.
|z StatID:(DE-HGF)0510
909 C O |o oai:bib-pubdb1.desy.de:317044
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Europäisches Laboratorium für Molekularbiologie
|0 I:(DE-588b)235011-7
|k EMBL
|b 6
|6 P:(DE-HGF)0
910 1 _ |a Europäisches Laboratorium für Molekularbiologie
|0 I:(DE-588b)235011-7
|k EMBL
|b 6
|6 P:(DE-HGF)0
913 1 _ |a DE-HGF
|b Programmungebundene Forschung
|l ohne Programm
|1 G:(DE-HGF)POF3-890
|0 G:(DE-HGF)POF3-899
|2 G:(DE-HGF)POF3-800
|v ohne Topic
|x 0
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
914 1 _ |y 2016
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
915 _ _ |a Embargoed OpenAccess
|0 StatID:(DE-HGF)0530
|2 StatID
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b J STRUCT BIOL : 2015
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Thomson Reuters Master Journal List
920 1 _ |0 I:(DE-H253)EMBL-20120731
|k EMBL
|l EMBL
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-H253)EMBL-20120731
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21