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@ARTICLE{Grinkevich:315131,
author = {Grinkevich, Pavel and Iermak, Iuliia and Luedtke, Nicholas
A. and Mesters, Jeroen R. and Ettrich, Rüdiger and Ludwig,
Jost},
title = {p{H}luorin-assisted expression, purification,
crystallization and {X}-ray diffraction data analysis of the
{C}-terminal domain of the {H}sd{R} subunit of the
{E}scherichia coli type {I} restriction-modification system
{E}co{R}124{I}},
journal = {Acta crystallographica / F},
volume = {72},
number = {9},
issn = {2053-230X},
publisher = {IUCr},
reportid = {PUBDB-2016-05653},
pages = {672 - 676},
year = {2016},
note = {(c) International Union of Crystallography},
abstract = {The HsdR subunit of the type I restriction-modification
system EcoR124I is responsible for the translocation as well
as the restriction activity of the whole complex consisting
of the HsdR, HsdM and HsdS subunits, and while crystal
structures are available for the wild type and several
mutants, the C-terminal domain comprising approximately 150
residues was not resolved in any of these structures. Here,
three fusion constructs with the GFP variant pHluorin
developed to overexpress, purify and crystallize the
C-terminal domain of HsdR are reported. The shortest of the
three encompassed HsdR residues 887-1038 and yielded
crystals that belonged to the orthorhombic space group
C222$_1$, with unit-cell parameters a = 83.42, b = 176.58, c
= 126.03 Å, $\alpha$ = $\beta$ = $\gamma$ = 90.00° and two
molecules in the asymmetric unit (V$_M$ = 2.55 Å$^3$
Da$^{-1}$, solvent content 50.47\%). X-ray diffraction data
were collected to a resolution of 2.45 Å.},
cin = {EMBL-User},
ddc = {530},
cid = {I:(DE-H253)EMBL-User-20120814},
pnm = {6G3 - PETRA III (POF3-622) / BIOSTRUCT-X - Transnational
access and enhancement of integrated Biological Structure
determination at synchrotron X-ray radiation facilities
(283570)},
pid = {G:(DE-HGF)POF3-6G3 / G:(EU-Grant)283570},
experiment = {EXP:(DE-H253)P-P13-20150101},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000384167800003},
pubmed = {pmid:27599856},
doi = {10.1107/S2053230X16011626},
url = {https://bib-pubdb1.desy.de/record/315131},
}