TY  - JOUR
AU  - Zarrine-Afsar, Arash
AU  - Barends, Thomas R. M.
AU  - Müller, Christina
AU  - Fuchs, Martin R.
AU  - Lomb, Lukas
AU  - Schlichting, Ilme
AU  - Miller, R. J. Dwayne
TI  - Crystallography on a chip
JO  - Acta crystallographica / D
VL  - 68
IS  - 3
SN  - 1399-0047
CY  - Oxford
PB  - Wiley-Blackwell
M1  - PUBDB-2016-02227
SP  - 321 - 323
PY  - 2012
AB  - A new chip-based crystal-mounting approach for rapid room-temperature data collection from numerous crystals is described. This work was motivated by the recent development of X-ray free-electron lasers. These novel sources deliver very intense femtosecond X-ray pulses that promise to yield high-resolution diffraction data of nanocrystals before their destruction by radiation damage. Thus, the concept of `diffraction before destruction' requires rapid replenishment of the sample for each exposure. The chip promotes the self-assembly of an array of protein crystals on a surface. Rough features on the surface cause the crystals to adopt random orientations, allowing efficient sampling of reciprocal space.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000300444300014
C6  - pmid:22349234
DO  - DOI:10.1107/S0907444911055296
UR  - https://bib-pubdb1.desy.de/record/300245
ER  -