%0 Journal Article
%A Zarrine-Afsar, Arash
%A Barends, Thomas R. M.
%A Müller, Christina
%A Fuchs, Martin R.
%A Lomb, Lukas
%A Schlichting, Ilme
%A Miller, R. J. Dwayne
%T Crystallography on a chip
%J Acta crystallographica / D
%V 68
%N 3
%@ 1399-0047
%C Oxford
%I Wiley-Blackwell
%M PUBDB-2016-02227
%P 321 - 323
%D 2012
%X A new chip-based crystal-mounting approach for rapid room-temperature data collection from numerous crystals is described. This work was motivated by the recent development of X-ray free-electron lasers. These novel sources deliver very intense femtosecond X-ray pulses that promise to yield high-resolution diffraction data of nanocrystals before their destruction by radiation damage. Thus, the concept of `diffraction before destruction' requires rapid replenishment of the sample for each exposure. The chip promotes the self-assembly of an array of protein crystals on a surface. Rough features on the surface cause the crystals to adopt random orientations, allowing efficient sampling of reciprocal space.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000300444300014
%$ pmid:22349234
%R 10.1107/S0907444911055296
%U https://bib-pubdb1.desy.de/record/300245