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@ARTICLE{Anand:296558,
      author       = {Anand, Roopsee and Eschenburg, Susanne and Reubold, Thomas
                      F.},
      title        = {{C}rystal structure of the {GTP}ase domain and the bundle
                      signalling element of dynamin in the {GDP} state},
      journal      = {Biochemical and biophysical research communications},
      volume       = {469},
      number       = {1},
      issn         = {0006-291X},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {PUBDB-2016-01538},
      pages        = {76 - 80},
      year         = {2016},
      abstract     = {Dynamin is the prototype of a family of large multi-domain
                      GTPases. The 100 kDa protein is a key playerin
                      clathrin-mediated endocytosis, where it cleaves off vesicles
                      from membranes using the energy fromGTP hydrolysis. We have
                      solved the high resolution crystal structure of a fusion
                      protein of the GTPasedomain and the bundle signalling
                      element (BSE) of dynamin 1 liganded with GDP. The structure
                      providesa hitherto missing snapshot of the GDP state of the
                      hydrolytic cycle of dynamin and reveals how theswitch I
                      region moves away from the active site after GTP hydrolysis
                      and release of inorganic phosphate.Comparing our structure
                      of the GDP state with the known structures of the GTP state,
                      the transition stateand the nucleotide-free state of dynamin
                      1 we describe the structural changes through the
                      hydrolyticcycle.},
      cin          = {DOOR},
      ddc          = {570},
      cid          = {I:(DE-H253)HAS-User-20120731},
      pnm          = {6G3 - PETRA III (POF3-622)},
      pid          = {G:(DE-HGF)POF3-6G3},
      experiment   = {EXP:(DE-H253)P-P11-20150101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000368868000012},
      pubmed       = {pmid:26612256},
      doi          = {10.1016/j.bbrc.2015.11.074},
      url          = {https://bib-pubdb1.desy.de/record/296558},
}