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@ARTICLE{Martin:293484,
      author       = {Martin, Andrew V. and Corso, Justine K. and Caleman, Carl
                      and Timneanu, Nicusor and Quiney, Harry M.},
      title        = {{S}ingle-molecule imaging with longer {X}-ray laser pulses},
      journal      = {IUCrJ},
      volume       = {2},
      number       = {6},
      issn         = {2052-2525},
      address      = {Chester},
      publisher    = {International Union of Crystallography (IUCr)},
      reportid     = {PUBDB-2016-00573},
      pages        = {661 - 674},
      year         = {2015},
      abstract     = {During the last five years, serial femtosecond
                      crystallography using X-ray laser pulses has been developed
                      into a powerful technique for determining the atomic
                      structures of protein molecules from micrometre- and
                      sub-micrometre-sized crystals. One of the key reasons for
                      this success is the `self-gating' pulse effect, whereby the
                      X-ray laser pulses do not need to outrun all radiation
                      damage processes. Instead, X-ray-induced damage terminates
                      the Bragg diffraction prior to the pulse completing its
                      passage through the sample, as if the Bragg diffraction were
                      generated by a shorter pulse of equal intensity. As a
                      result, serial femtosecond crystallography does not need to
                      be performed with pulses as short as 5–10 fs, but can
                      succeed for pulses 50–100 fs in duration. It is shown
                      here that a similar gating effect applies to single-molecule
                      diffraction with respect to spatially uncorrelated damage
                      processes like ionization and ion diffusion. The effect is
                      clearly seen in calculations of the diffraction contrast, by
                      calculating the diffraction of the average structure
                      separately to the diffraction from statistical fluctuations
                      of the structure due to damage (`damage noise'). The results
                      suggest that sub-nanometre single-molecule imaging with
                      30–50 fs pulses, like those produced at currently
                      operating facilities, should not yet be ruled out. The
                      theory presented opens up new experimental avenues to
                      measure the impact of damage on single-particle diffraction,
                      which is needed to test damage models and to identify
                      optimal imaging conditions.},
      cin          = {FS-CFEL-1},
      ddc          = {530},
      cid          = {I:(DE-H253)FS-CFEL-1-20120731},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621)},
      pid          = {G:(DE-HGF)POF3-6215},
      experiment   = {EXP:(DE-MLZ)NOSPEC-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000364415900011},
      pubmed       = {pmid:26594374},
      doi          = {10.1107/S2052252515016887},
      url          = {https://bib-pubdb1.desy.de/record/293484},
}