TY  - JOUR
AU  - Fenalti, Gustavo
AU  - Zatsepin, Nadia A
AU  - Betti, Cecilia
AU  - Giguere, Patrick
AU  - Han, Gye Won
AU  - Ishchenko, Andrii
AU  - Liu, Wei
AU  - Guillemyn, Karel
AU  - Zhang, Haitao
AU  - James, Daniel
AU  - Wang, Dingjie
AU  - Weierstall, Uwe
AU  - Spence, John C H
AU  - Boutet, Sébastien
AU  - Messerschmidt, Marc
AU  - Williams, Garth J
AU  - Gati, Cornelius
AU  - Yefanov, Oleksandr
AU  - White, Thomas
AU  - Oberthuer, Dominik
AU  - Metz, Markus
AU  - Yoon, Chun Hong
AU  - Barty, Anton
AU  - Chapman, Henry N.
AU  - Basu, Shibom
AU  - Coe, Jesse
AU  - Conrad, Chelsie E
AU  - Fromme, Raimund
AU  - Fromme, Petra
AU  - Tourwé, Dirk
AU  - Schiller, Peter W
AU  - Roth, Bryan L
AU  - Ballet, Steven
AU  - Katritch, Vsevolod
AU  - Stevens, Raymond C
AU  - Cherezov, Vadim
TI  - Structural basis for bifunctional peptide recognition at human δ-opioid receptor
JO  - Nature structural & molecular biology
VL  - 22
IS  - 3
SN  - 1545-9985
CY  - London [u.a.]
PB  - Nature Publishing Group
M1  - PUBDB-2016-00256
SP  - 265 - 268
PY  - 2015
N1  - (c) Nature America, Inc.
AB  - Bifunctional μ- and ​δ-opioid receptor (OR) ligands are potential therapeutic alternatives, with diminished side effects, to alkaloid opiate analgesics. We solved the structure of human ​δ-OR bound to the bifunctional ​δ-OR antagonist and ​μ-OR agonist tetrapeptide ​H-Dmt-Tic-Phe-Phe-NH2 (​DIPP-NH2) by serial femtosecond crystallography, revealing a cis-peptide bond between ​H-Dmt and ​Tic. The observed receptor-peptide interactions are critical for understanding of the pharmacological profiles of opioid peptides and for development of improved analgesics.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000350531000017
C6  - pmid:25686086
DO  - DOI:10.1038/nsmb.2965
UR  - https://bib-pubdb1.desy.de/record/293073
ER  -