%0 Journal Article
%A Fenalti, Gustavo
%A Zatsepin, Nadia A
%A Betti, Cecilia
%A Giguere, Patrick
%A Han, Gye Won
%A Ishchenko, Andrii
%A Liu, Wei
%A Guillemyn, Karel
%A Zhang, Haitao
%A James, Daniel
%A Wang, Dingjie
%A Weierstall, Uwe
%A Spence, John C H
%A Boutet, Sébastien
%A Messerschmidt, Marc
%A Williams, Garth J
%A Gati, Cornelius
%A Yefanov, Oleksandr
%A White, Thomas
%A Oberthuer, Dominik
%A Metz, Markus
%A Yoon, Chun Hong
%A Barty, Anton
%A Chapman, Henry N.
%A Basu, Shibom
%A Coe, Jesse
%A Conrad, Chelsie E
%A Fromme, Raimund
%A Fromme, Petra
%A Tourwé, Dirk
%A Schiller, Peter W
%A Roth, Bryan L
%A Ballet, Steven
%A Katritch, Vsevolod
%A Stevens, Raymond C
%A Cherezov, Vadim
%T Structural basis for bifunctional peptide recognition at human δ-opioid receptor
%J Nature structural & molecular biology
%V 22
%N 3
%@ 1545-9985
%C London [u.a.]
%I Nature Publishing Group
%M PUBDB-2016-00256
%P 265 - 268
%D 2015
%Z (c) Nature America, Inc.
%X Bifunctional μ- and ​δ-opioid receptor (OR) ligands are potential therapeutic alternatives, with diminished side effects, to alkaloid opiate analgesics. We solved the structure of human ​δ-OR bound to the bifunctional ​δ-OR antagonist and ​μ-OR agonist tetrapeptide ​H-Dmt-Tic-Phe-Phe-NH2 (​DIPP-NH2) by serial femtosecond crystallography, revealing a cis-peptide bond between ​H-Dmt and ​Tic. The observed receptor-peptide interactions are critical for understanding of the pharmacological profiles of opioid peptides and for development of improved analgesics.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000350531000017
%$ pmid:25686086
%R 10.1038/nsmb.2965
%U https://bib-pubdb1.desy.de/record/293073